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    Zfp777 zinc finger protein 777 [ Mus musculus (house mouse) ]

    Gene ID: 72306, updated on 27-Nov-2024

    Summary

    Official Symbol
    Zfp777provided by MGI
    Official Full Name
    zinc finger protein 777provided by MGI
    Primary source
    MGI:MGI:1919556
    See related
    Ensembl:ENSMUSG00000071477 AllianceGenome:MGI:1919556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2500002G23Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of cell population proliferation; protein heterooligomerization; and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; retina; and tooth. Orthologous to human ZNF777 (zinc finger protein 777). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.7), ovary adult (RPKM 6.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zfp777 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.0 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47994594..48026963, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48017660..48050004, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15786 Neighboring gene nuclear encoded tRNA cysteine 57 (anticodon GCA) Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15788 Neighboring gene zinc finger protein 746 Neighboring gene nuclear encoded tRNA cysteine 37 (anticodon GCA) Neighboring gene predicted gene, 30435 Neighboring gene predicted gene, 16630

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081382.2NP_001074851.1  zinc finger protein 777 isoform 1

      See identical proteins and their annotated locations for NP_001074851.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC166290
      Consensus CDS
      CCDS39477.1
      UniProtKB/TrEMBL
      B9EKF4
      Related
      ENSMUSP00000110230.2, ENSMUST00000114583.8
      Conserved Domains (8) summary
      smart00349
      Location:328388
      KRAB; krueppel associated box
      COG5048
      Location:694880
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:750770
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:723740
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:748770
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:328367
      KRAB; KRAB box
      pfam13465
      Location:762786
      zf-H2C2_2; Zinc-finger double domain
      pfam14353
      Location:691740
      CpXC; CpXC protein
    2. NM_001347139.1NP_001334068.1  zinc finger protein 777 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC166290
      Consensus CDS
      CCDS85035.1
      UniProtKB/TrEMBL
      G5E8L5
      Conserved Domains (7) summary
      smart00349
      Location:284344
      KRAB; krueppel associated box
      COG5048
      Location:650836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198254
      DUF3669; Zinc finger protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47994594..48026963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506675.4XP_006506738.2  zinc finger protein 777 isoform X3

      Conserved Domains (2) summary
      smart00349
      Location:470530
      KRAB; krueppel associated box
      pfam12417
      Location:384440
      DUF3669; Zinc finger protein
    2. XM_006506673.5XP_006506736.1  zinc finger protein 777 isoform X2

      See identical proteins and their annotated locations for XP_006506736.1

      UniProtKB/TrEMBL
      G5E8L5
      Related
      ENSMUSP00000093637.4, ENSMUST00000095944.10
      Conserved Domains (7) summary
      smart00349
      Location:284344
      KRAB; krueppel associated box
      COG5048
      Location:650836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198254
      DUF3669; Zinc finger protein
    3. XM_011241478.4XP_011239780.1  zinc finger protein 777 isoform X2

      See identical proteins and their annotated locations for XP_011239780.1

      UniProtKB/TrEMBL
      G5E8L5
      Conserved Domains (7) summary
      smart00349
      Location:284344
      KRAB; krueppel associated box
      COG5048
      Location:650836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198254
      DUF3669; Zinc finger protein
    4. XM_006506674.5XP_006506737.1  zinc finger protein 777 isoform X2

      See identical proteins and their annotated locations for XP_006506737.1

      UniProtKB/TrEMBL
      G5E8L5
      Conserved Domains (7) summary
      smart00349
      Location:284344
      KRAB; krueppel associated box
      COG5048
      Location:650836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198254
      DUF3669; Zinc finger protein
    5. XM_006506671.5XP_006506734.1  zinc finger protein 777 isoform X1

      Conserved Domains (7) summary
      smart00349
      Location:307367
      KRAB; krueppel associated box
      COG5048
      Location:673859
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:729749
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:702719
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:580602
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:14203
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:221277
      DUF3669; Zinc finger protein

    RNA

    1. XR_003956255.2 RNA Sequence