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    MSBP1 membrane steroid binding protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835300, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSBP1
    Official Full Name
    membrane steroid binding protein 1
    Primary source
    TAIR:AT5G52240
    Locus tag
    AT5G52240
    See related
    Araport:AT5G52240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MEMBRANE-ASSOCIATED PROGESTERONE BINDING PROTEIN 5; AtMAPR5; ATMP1; F17P19.14; F17P19_14; membrane steroid binding protein 1
    Summary
    Encodes a protein with similarity to progesterone-binding proteins in animals. Has been shown to bind steroids in vitro. Expressed in aerial portions of the plant excluding mature flowers and siliques. Antisense experiments suggest a role in inhibition of hypocotyl cell elongation. Expression is suppressed light grown seedlings transferred to the dark.
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    Genomic context

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    See MSBP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (21212940..21214842)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene GTP-binding protein 1 Neighboring gene chromosome transmission fidelity-like protein Neighboring gene methyl-CPG-binding domain protein 13 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene myb domain protein 19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane steroid binding protein 1 (MSBP1) stimulates tropism by regulating vesicle trafficking and auxin redistribution. Yang X, et al. Mol Plant, 2008 Nov. PMID 19825605
    2. The scaffold proteins of lignin biosynthetic cytochrome P450 enzymes. Gou M, et al. Nat Plants, 2018 May. PMID 29725099
    3. Arabidopsis membrane steroid binding protein 1 is involved in inhibition of cell elongation. Yang XH, et al. Plant Cell, 2005 Jan. PMID 15608331, Free PMC Article
    4. Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation. Shi QM, et al. Mol Plant, 2011 Nov. PMID 21715650
    5. Membrane steroid-binding protein 1 (MSBP1) negatively regulates brassinosteroid signaling by enhancing the endocytosis of BAK1. Song L, et al. Cell Res, 2009 Jul. PMID 19532123

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MSBP1 protein is essential structural component in the endoplasmic reticulum membrane that physically organizes and stabilizes the monolignol biosynthetic P450 enzyme complex.
      Title: The scaffold proteins of lignin biosynthetic cytochrome P450 enzymes.
    2. light triggers MSBP1 expression through direct binding to and activation by HY5 and HYH.
      Title: Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation.
    3. MSBP1 could enhance the cycling of PIN2-containing vesicles to stimulate the auxin redistribution under gravi-stimulation.
      Title: Membrane steroid binding protein 1 (MSBP1) stimulates tropism by regulating vesicle trafficking and auxin redistribution.
    4. MSBP1 enhances BAK1 endocytosis by interacting with its extracellular region, resulting in the reduced association of BRI1 and BAK1, and suppressed brassinosteroid signaling.
      Title: Membrane steroid-binding protein 1 (MSBP1) negatively regulates brassinosteroid signaling by enhancing the endocytosis of BAK1.
    5. Expression of MSBP1 in hypocotyls is suppressed by darkness and activated by light, suggesting that MSBP1, as a negative regulator of cell elongation, plays a role in plant photomorphogenesis. [MSBP1]
      Title: Arabidopsis membrane steroid binding protein 1 is involved in inhibition of cell elongation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203592.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    membrane steroid binding protein 1
    NP_001190521.1
    • membrane steroid binding protein 1 (MSBP1); CONTAINS InterPro DOMAIN/s: Cytochrome b5 (InterPro:IPR001199); BEST Arabidopsis thaliana protein match is: membrane-associated progesterone binding protein 3 (TAIR:AT3G48890.1).
    NP_200037.1
    • membrane steroid binding protein 1 (MSBP1); FUNCTIONS IN: steroid binding; INVOLVED IN: negative regulation of cell growth; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome b5 (InterPro:IPR001199); BEST Arabidopsis thaliana protein match is: membrane-associated progesterone binding protein 3 (TAIR:AT3G48890.1); Has 1072 Blast hits to 1062 proteins in 198 species: Archae - 0; Bacteria - 0; Metazoa - 430; Fungi - 335; Plants - 200; Viruses - 0; Other Eukaryotes - 107 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21212940..21214842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124603.4 → NP_200037.1  membrane steroid binding protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200037.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTJ7, Q9XFM6
      UniProtKB/TrEMBL
      A0A178UD31, A0A5S9YD89
      Conserved Domains (1) summary
      pfam00173
      Location:74 → 170
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    2. NM_001203592.2 → NP_001190521.1  membrane steroid binding protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KG44
      Conserved Domains (1) summary
      pfam00173
      Location:74 → 170
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XFM6.2

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