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    Lcat lecithin cholesterol acyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 16816, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lcatprovided by MGI
    Official Full Name
    lecithin cholesterol acyltransferaseprovided by MGI
    Primary source
    MGI:MGI:96755
    See related
    Ensembl:ENSMUSG00000035237 AllianceGenome:MGI:96755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D8Wsu61e
    Summary
    Enables phosphatidylcholine-sterol O-acyltransferase activity and platelet-activating factor acetyltransferase activity. Involved in regulation of high-density lipoprotein particle assembly. Acts upstream of or within cholesterol metabolic process and lipoprotein biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Used to study Norum disease. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 395.2), liver E18 (RPKM 118.1) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lcat in Genome Data Viewer
    Location:
    8 D3; 8 53.06 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106666183..106670034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105939551..105943402, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene chymotrypsin-like Neighboring gene proteasome (prosome, macropain) subunit, beta type 10 Neighboring gene solute carrier family 12, member 4 Neighboring gene microRNA 7074 Neighboring gene STARR-seq mESC enhancer starr_22546 Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lipoprotein biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of high-density lipoprotein particle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reverse cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in very-low-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very-low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylcholine-sterol acyltransferase
    Names
    1-alkyl-2-acetylglycerophosphocholine esterase
    PAF acetylhydrolase
    lecithin-cholesterol acyltransferase Lcat
    phospholipid-cholesterol acyltransferase
    platelet-activating factor acetylhydrolase
    NP_032516.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008490.2NP_032516.2  phosphatidylcholine-sterol acyltransferase precursor

      See identical proteins and their annotated locations for NP_032516.2

      Status: VALIDATED

      Source sequence(s)
      AI046659, AI574112, AK149476
      Consensus CDS
      CCDS22622.1
      UniProtKB/Swiss-Prot
      P16301, Q8K139
      UniProtKB/TrEMBL
      Q791M3
      Related
      ENSMUSP00000038232.8, ENSMUST00000038896.8
      Conserved Domains (1) summary
      cl21494
      Location:83408
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106666183..106670034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)