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    GS1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835849, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GS1
    Official Full Name
    Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
    Primary source
    TAIR:AT5G57440
    Locus tag
    AT5G57440
    See related
    Araport:AT5G57440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GLYCEROL-3-PHOSPHATASE 2; GPP2; MUA2.2; MUA2_2
    Summary
    a member of haloacid dehalogenase-like hydrolase family
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    Genomic context

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    See GS1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (23271114..23273021, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Afadin/alpha-actinin-binding protein Neighboring gene indole-3-acetic acid inducible 33 Neighboring gene homolog of X-ray repair cross complementing 3 (XRCC3) Neighboring gene muniscin carboxy-terminal mu-like domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence Determinants of Substrate Ambiguity in a HAD Phosphosugar Phosphatase of Arabidopsis Thaliana. Caparrós-Martín JA, et al. Biology (Basel), 2019 Oct 9. PMID 31601035, Free PMC Article
    2. Cytosolic Glutamine Synthetase Gln1;2 Is the Main Isozyme Contributing to GS1 Activity and Can Be Up-Regulated to Relieve Ammonium Toxicity. Guan M, et al. Plant Physiol, 2016 Jul. PMID 27231101, Free PMC Article
    3. Arabidopsis thaliana AtGppl and AtGpp2: two novel low molecular weight phosphatases involved in plant glycerol metabolism. Caparrós-Martín JA, et al. Plant Mol Biol, 2007 Mar. PMID 17136424
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLN1;2 contributes to shoot GS1 activity in vegetative growth stages.
      Title: Cytosolic Glutamine Synthetase Gln1;2 Is the Main Isozyme Contributing to GS1 Activity and Can Be Up-Regulated to Relieve Ammonium Toxicity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125126.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glycerol-1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
    NP_568858.1
    • GS1; FUNCTIONS IN: hydrolase activity, catalytic activity; INVOLVED IN: metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), HAD-superfamily hydrolase, subfamily IA, variant 3 (InterPro:IPR006402); BEST Arabidopsis thaliana protein match is: glycerol-3-phosphatase 1 (TAIR:AT4G25840.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23271114..23273021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125126.3 → NP_568858.1  Haloacid dehalogenase-like hydrolase (HAD) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VZP1, Q9FKM6
      UniProtKB/TrEMBL
      A0A178UIK6, A0A5S9YFD2
      Conserved Domains (1) summary
      PLN02811
      Location:21 → 240
      PLN02811; hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZP1.1

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