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    Neutral/alkaline non-lysosomal ceramidase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836015, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Neutral/alkaline non-lysosomal ceramidase
    Primary source
    TAIR:AT5G58980
    Locus tag
    AT5G58980
    See related
    Araport:AT5G58980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K19M22.22; K19M22_22
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (23811449..23814683, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene glucose-6-phosphate isomerase, putative (DUF641) Neighboring gene ncRNA Neighboring gene uncoupling protein 2 Neighboring gene 28S ribosomal S34 protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene kinase with tetratricopeptide repeat domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis neutral ceramidase mutant ncer1 accumulates hydroxyceramides and is sensitive to oxidative stress. Li J, et al. Front Plant Sci, 2015. PMID 26150824, Free PMC Article
    2. The Arabidopsis ceramidase AtACER functions in disease resistance and salt tolerance. Wu JX, et al. Plant J, 2015 Mar. PMID 25619405
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_125288.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N-acylsphingosine amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Neutral/alkaline non-lysosomal ceramidase
    NP_200706.1
    • Neutral/alkaline non-lysosomal ceramidase; FUNCTIONS IN: ceramidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Neutral/alkaline nonlysosomal ceramidase (InterPro:IPR006823); BEST Arabidopsis thaliana protein match is: Neutral/alkaline non-lysosomal ceramidase (TAIR:AT1G07380.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23811449..23814683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125288.4 → NP_200706.1  Neutral/alkaline non-lysosomal ceramidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200706.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KHQ8, Q93ZI6, Q9FIL4
      UniProtKB/TrEMBL
      A0A654GCH1
      Conserved Domains (2) summary
      pfam04734
      Location:29 → 565
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:567 → 732
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KHQ8.1

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