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    ML1 MEI2-like protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836317, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ML1
    Official Full Name
    MEI2-like protein 1
    Primary source
    TAIR:AT5G61960
    Locus tag
    AT5G61960
    See related
    Araport:AT5G61960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AML1; K22G18.10; K22G18_10; MEI2-like protein 1
    Summary
    A member of mei2-like gene family, predominantly plant-based family of genes encoding RNA binding proteins with characteristic presence of a highly conserved RNA binding motif first described in the mei2 gene of the fission yeast S. pombe. In silico analyses reveal nine mei2 -like genes in A. thaliana. They were grouped into four distinct clades, based on overall sequence similarity and subfamily-specific sequence elements. AML1 is a member of two sister clades of mei2-like gene family, AML1 through AML5 and belongs to the clade named ALM14. AML1 is expressed during early embryo development, particularly along embryonic axis at torpedo stage, in shoot apex (weaker expression) and in the organogenic regions of floral apices.
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    Genomic context

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    See ML1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (24878507..24884852, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene APO RNA-binding protein (DUF794) Neighboring gene Ubiquitin carboxyl-terminal hydrolase-related protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase-related protein Neighboring gene signal recognition particle-related / SRP-like protein Neighboring gene ARF-GAP domain 1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional cloning of a cDNA encoding Mei2-like protein from Arabidopsis thaliana using a fission yeast pheromone receptor deficient mutant. Hirayama T, et al. FEBS Lett, 1997 Aug 11. PMID 9287109
    2. The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth. Anderson GH, et al. BMC Plant Biol, 2005 Feb 21. PMID 15720729, Free PMC Article
    3. The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Kaur J, et al. Plant Cell, 2006 Mar. PMID 16473967, Free PMC Article
    4. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
    5. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001037045.1
    NM_001345510.1
    NM_001345511.1
    NM_001345512.1
    NM_001345513.1
    NM_001345514.1
    NM_001345515.1
    NM_001345516.1
    NM_001345517.1
    NM_001345518.1
    NM_125589.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within meristem development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of meiotic nuclear division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MEI2-like protein 1
    NP_001318861.1
    • MEI2-like protein 1 (ML1); CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), RNA recognition motif 2 (InterPro:IPR007201), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: MEI2-like 4 (TAIR:AT5G07290.1); Has 4583 Blast hits to 4209 proteins in 289 species: Archae - 0; Bacteria - 6; Metazoa - 2486; Fungi - 644; Plants - 914; Viruses - 0; Other Eukaryotes - 533 (source: NCBI BLink).
    NP_568946.1
    • MEI2-like protein 1 (ML1); CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), RNA recognition motif 2 (InterPro:IPR007201), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: MEI2-like 4 (TAIR:AT5G07290.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24878507..24884852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125589.5 → NP_568946.1  MEI2-like protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23866, Q8W4I9
      UniProtKB/TrEMBL
      A0A178UI32, A0A654GDT7
      Conserved Domains (3) summary
      pfam04059
      Location:743 → 839
      RRM_2; RNA recognition motif 2
      cd12276
      Location:301 → 371
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:216 → 292
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    2. NM_001345515.1 → NP_001330766.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI32, A0A1P8BBU0, A0A7G2FPB8
      Conserved Domains (3) summary
      pfam04059
      Location:736 → 832
      RRM_2; RNA recognition motif 2
      cd12276
      Location:294 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:209 → 285
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    3. NM_001345511.1 → NP_001318861.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23866, Q8W4I9
      UniProtKB/TrEMBL
      A0A178UI32, A0A654GDT7
      Conserved Domains (3) summary
      pfam04059
      Location:743 → 839
      RRM_2; RNA recognition motif 2
      cd12276
      Location:301 → 371
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:216 → 292
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    4. NM_001345510.1 → NP_001330764.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI32, A0A1P8BBU0, A0A7G2FPB8
      Conserved Domains (3) summary
      pfam04059
      Location:736 → 832
      RRM_2; RNA recognition motif 2
      cd12276
      Location:294 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:209 → 285
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    5. NM_001345516.1 → NP_001330767.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI32, A0A1P8BBU0, A0A7G2FPB8
      Conserved Domains (3) summary
      pfam04059
      Location:736 → 832
      RRM_2; RNA recognition motif 2
      cd12276
      Location:294 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:209 → 285
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    6. NM_001345513.1 → NP_001330768.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI32, A0A1P8BBU0, A0A7G2FPB8
      Conserved Domains (3) summary
      pfam04059
      Location:736 → 832
      RRM_2; RNA recognition motif 2
      cd12276
      Location:294 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:209 → 285
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    7. NM_001345512.1 → NP_001330765.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23866, Q8W4I9
      UniProtKB/TrEMBL
      A0A178UI32, A0A654GDT7
      Conserved Domains (3) summary
      pfam04059
      Location:743 → 839
      RRM_2; RNA recognition motif 2
      cd12276
      Location:301 → 371
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:216 → 292
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    8. NM_001345518.1 → NP_001330771.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI32, A0A1P8BBU0, A0A7G2FPB8
      Conserved Domains (3) summary
      pfam04059
      Location:736 → 832
      RRM_2; RNA recognition motif 2
      cd12276
      Location:294 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:209 → 285
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    9. NM_001345517.1 → NP_001330770.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI32, A0A1P8BBU0, A0A7G2FPB8
      Conserved Domains (3) summary
      pfam04059
      Location:736 → 832
      RRM_2; RNA recognition motif 2
      cd12276
      Location:294 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:209 → 285
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    10. NM_001345514.1 → NP_001330769.1  MEI2-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI32, A0A1P8BBU0, A0A7G2FPB8
      Conserved Domains (3) summary
      pfam04059
      Location:736 → 832
      RRM_2; RNA recognition motif 2
      cd12276
      Location:294 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:209 → 285
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins

    11. NM_001037045.1 → NP_001032122.1  MEI2-like protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032122.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23866, Q8W4I9
      UniProtKB/TrEMBL
      A0A178UI32, A0A654GDT7
      Conserved Domains (3) summary
      pfam04059
      Location:743 → 839
      RRM_2; RNA recognition motif 2
      cd12276
      Location:301 → 371
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 (RRM2) found in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:216 → 292
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4I9.1

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