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    BAG7 BCL-2-associated athanogene 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836360, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BAG7
    Official Full Name
    BCL-2-associated athanogene 7
    Primary source
    TAIR:AT5G62390
    Locus tag
    AT5G62390
    See related
    Araport:AT5G62390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBAG7; BCL-2-associated athanogene 7; MMI9.22; MMI9_22
    Summary
    A member of Arabidopsis BAG (Bcl-2-associated athanogene) proteins, plant homologs of mammalian regulators of apoptosis. Plant BAG proteins are multi-functional and remarkably similar to their animal counterparts, as they regulate apoptotic-like processes ranging from pathogen attack, to abiotic stress, to plant development. Localized to the ER. Necessary for the proper maintenance of the unfolded protein response during heat and cold tolerance.
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    Genomic context

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    See BAG7 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (25051978..25054444, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene NAC-domain protein 101 Neighboring gene uncharacterized protein Neighboring gene structural maintenance of chromosomes 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis B-cell lymphoma2 (Bcl-2)-associated athanogene 7 (BAG7)-mediated heat tolerance requires translocation, sumoylation and binding to WRKY29. Li Y, et al. New Phytol, 2017 Apr. PMID 28032645
    2. AtBAG7, an Arabidopsis Bcl-2-associated athanogene, resides in the endoplasmic reticulum and is involved in the unfolded protein response. Williams B, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231441, Free PMC Article
    3. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
    4. Interactomics of Qa-SNARE in Arabidopsis thaliana. Fujiwara M, et al. Plant Cell Physiol, 2014 Apr. PMID 24556609
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upon heat stress, AtBAG7 is sumoylated, proteolytically processed and translocated from the endoplasmic reticulum to the nucleus, where interaction with the WRKY29 transcription factor occurs.
      Title: Arabidopsis B-cell lymphoma2 (Bcl-2)-associated athanogene 7 (BAG7)-mediated heat tolerance requires translocation, sumoylation and binding to WRKY29.
    2. BAG7 knockouts were sensitive to known ER stress stimuli, heat and cold, confirming the cytoprotective role of plant BAGs.
      Title: AtBAG7, an Arabidopsis Bcl-2-associated athanogene, resides in the endoplasmic reticulum and is involved in the unfolded protein response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125633.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    BCL-2-associated athanogene 7
    NP_201045.1
    • BCL-2-associated athanogene 7 (BAG7); FUNCTIONS IN: protein binding, calmodulin binding; INVOLVED IN: protein folding, cellular response to unfolded protein, cellular response to cold, cellular response to heat; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: IQ calmodulin-binding region (InterPro:IPR000048); Has 7138 Blast hits to 4774 proteins in 502 species: Archae - 15; Bacteria - 776; Metazoa - 2268; Fungi - 700; Plants - 404; Viruses - 26; Other Eukaryotes - 2949 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25051978..25054444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125633.5 → NP_201045.1  BCL-2-associated athanogene 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201045.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LVA0
      UniProtKB/TrEMBL
      A0A5S9YGJ1, A0A654GDA9, A0A7G2FPF5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LVA0.1

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