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    l(2)37Cd lethal (2) 37Cd [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)37Cdprovided by FlyBase
    Official Full Name
    lethal (2) 37Cdprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086445
    Locus tag
    Dmel_CG10563
    See related
    AllianceGenome:FB:FBgn0086445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cd; CG10563; Dmel\CG10563
    Summary
    Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be part of transcription factor TFIIIC complex. Is expressed in organism. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)37Cd in Genome Data Viewer
    Location:
    37C1-37C1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19127260..19129326)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19127260..19129326)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Prohibitin 1 Neighboring gene lethal (2) 37Cb Neighboring gene Asparaginyl-tRNA synthetase Neighboring gene Dynactin 6, p27 subunit Neighboring gene RNA polymerase I and III subunit D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental control of transduced dopa decarboxylase genes in D. melanogaster. Marsh JL, et al. Mol Gen Genet, 1985. PMID 2989656
    2. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
    3. Modulated modularity clustering as an exploratory tool for functional genomic inference. Stone EA, et al. PLoS Genet, 2009 May. PMID 19424432, Free PMC Article
    4. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region. Pentz ES, et al. Genetics, 1986 Apr. PMID 3007281, Free PMC Article
    5. Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. Gilbert D, et al. Genetics, 1984 Apr. PMID 6425116, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription initiation at RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 37Cd
    Names
    CG10563-PA
    l(2)37Cd-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19127260..19129326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136103.3 → NP_609947.1  lethal (2) 37Cd [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIF0, Q9VIZ2
      Related
      FBpp0080700
      Conserved Domains (1) summary
      pfam09734
      Location:13 → 303
      Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BIF0 Q5BIF0
    Q961P2 Q961P2
    Q9VIZ2 Q9VIZ2

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