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    IREG3 iron-regulated protein 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832740, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IREG3
    Official Full Name
    iron-regulated protein 3
    Primary source
    TAIR:AT5G26820
    Locus tag
    AT5G26820
    See related
    Araport:AT5G26820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATIREG3; F2P16.6; F2P16_6; IRON REGULATED 3; iron-regulated protein 3; MAR1; MULTIPLE ANTIBIOTIC RESISTANCE 1; RTS3
    Summary
    Mutations in MAR1 confer resistance, while MAR1 overexpression causes hypersensitivity to multiple aminoglycoside antibiotics. Localizes to the chloroplast envelope. MAR1 may act as a plastid transporter involved in cellular iron homeostasis.
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    Genomic context

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    See IREG3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (9433569..9437158)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene B3 domain protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Threonyl-tRNA synthetase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Arabidopsis. Kim LJ, et al. Plant J, 2021 Jul. PMID 33884692, Free PMC Article
    2. The MAR1 transporter is an opportunistic entry point for antibiotics. Conte SS, et al. Plant Signal Behav, 2010 Jan. PMID 20592808, Free PMC Article
    3. Multiple antibiotic resistance in Arabidopsis is conferred by mutations in a chloroplast-localized transport protein. Conte S, et al. Plant Physiol, 2009 Oct. PMID 19675150, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_122564.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    iron-regulated protein 3
    NP_198034.2
    • iron-regulated protein 3 (IREG3); CONTAINS InterPro DOMAIN/s: Ferroporti-1 (InterPro:IPR009716), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: iron regulated 2 (TAIR:AT5G03570.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9433569..9437158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122564.5 → NP_198034.2  iron-regulated protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198034.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04629, Q8W4E7
      UniProtKB/TrEMBL
      A0A178UFP2, A0A654G577
      Conserved Domains (1) summary
      pfam06963
      Location:146 → 569
      FPN1; Ferroportin1 (FPN1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4E7.1

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