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    nito spenito [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nitoprovided by FlyBase
    Official Full Name
    spenitoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027548
    Locus tag
    Dmel_CG2910
    See related
    AllianceGenome:FB:FBgn0027548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH11110; cg2910; CG2910; Dm44A/spenito; Dmel\CG2910; DmSSp; dOTT; Nito; Spenito; SSLP
    Summary
    Predicted to enable mRNA binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; regulation of gene expression; and wing disc pattern formation. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including adult head; ganglia; imaginal disc; larval central nervous system; and ovary. Orthologous to several human genes including RBM15 (RNA binding motif protein 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nito in Genome Data Viewer
    Location:
    43F8-43F9; 2-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7962463..7969805)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3849968..3857310)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Septin 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 4 Neighboring gene Acetyl-CoA carboxylase Neighboring gene Nucleoporin at 44A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An autonomous metabolic role for Spen. Hazegh KE, et al. PLoS Genet, 2017 Jun. PMID 28640815, Free PMC Article
    2. Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development. Jemc J, et al. Genetics, 2006 May. PMID 16547102, Free PMC Article
    3. Homeodomain-interacting protein kinase (Hipk) phosphorylates the small SPOC family protein Spenito. Dewald DN, et al. Insect Mol Biol, 2014 Dec. PMID 25040100
    4. The large and small SPEN family proteins stimulate axon outgrowth during neurosecretory cell remodeling in Drosophila. Gu T, et al. Dev Biol, 2017 Nov 15. PMID 28916169
    5. The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders. Angelova MT, et al. Front Bioeng Biotechnol, 2018. PMID 29707539, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells.
      Title: Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells.
    2. Spenito, a small Spen family member, counteracted Spen function in fat regulation. Finally, mouse Spen and Spenito transcript levels scaled directly with body fat in vivo, suggesting a conserved role in fat liberation and catabolism. This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfunction.
      Title: An autonomous metabolic role for Spen.
    3. spenito has a critical role in sex determination in Drosophila melanogaster
      Title: spenito is required for sex determination in Drosophila melanogaster.
    4. Spen and Nito act redundantly downstream of TCF/Armadillo to activate many Wg transcriptional targets.
      Title: Spenito and Split ends act redundantly to promote Wingless signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    spenito
    Names
    CG2910-PA
    CG2910-PB
    CG2910-PC
    One twenty Two
    Spen-like protein
    nito-PA
    nito-PB
    nito-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7962463..7969805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136495.3 → NP_610339.1  spenito, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KMJ6, Q8T0B2
      Related
      FBpp0087934
      Conserved Domains (5) summary
      COG0724
      Location:56 → 223
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12308
      Location:98 → 175
      RRM1_Spen; RNA recognition motif 1 in the Spen (split end) protein family
      cd12309
      Location:312 → 390
      RRM2_Spen; RNA recognition motif 2 in the Spen (split end) protein family
      cd12310
      Location:397 → 467
      RRM3_Spen; RNA recognition motif 3 in the Spen (split end) protein family
      pfam07744
      Location:630 → 789
      SPOC; SPOC domain

    2. NM_165579.2 → NP_724633.1  spenito, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724633.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KMJ6, Q8T0B2
      Related
      FBpp0087933
      Conserved Domains (5) summary
      COG0724
      Location:56 → 223
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12308
      Location:98 → 175
      RRM1_Spen; RNA recognition motif 1 in the Spen (split end) protein family
      cd12309
      Location:312 → 390
      RRM2_Spen; RNA recognition motif 2 in the Spen (split end) protein family
      cd12310
      Location:397 → 467
      RRM3_Spen; RNA recognition motif 3 in the Spen (split end) protein family
      pfam07744
      Location:630 → 789
      SPOC; SPOC domain

    3. NM_001299245.1 → NP_001286174.1  spenito, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286174.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KMJ6, Q8T0B2
      Conserved Domains (5) summary
      COG0724
      Location:56 → 223
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12308
      Location:98 → 175
      RRM1_Spen; RNA recognition motif 1 in the Spen (split end) protein family
      cd12309
      Location:312 → 390
      RRM2_Spen; RNA recognition motif 2 in the Spen (split end) protein family
      cd12310
      Location:397 → 467
      RRM3_Spen; RNA recognition motif 3 in the Spen (split end) protein family
      pfam07744
      Location:630 → 789
      SPOC; SPOC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMJ6.1 Q7KMJ6
    Q95SU9 Q95SU9

    Gene LinkOut

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