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    Samtor S-adenosylmethionine sensor upstream of TORC1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Samtorprovided by FlyBase
    Official Full Name
    S-adenosylmethionine sensor upstream of TORC1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035035
    Locus tag
    Dmel_CG3570
    See related
    AllianceGenome:FB:FBgn0035035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3570; Dmel\CG3570; dSamtor; dSAMTOR; samtor; SAMTOR
    Summary
    Enables S-adenosyl-L-methionine binding activity and amino acid sensor activity. Involved in cellular response to amino acid starvation; cellular response to methionine; and negative regulation of TORC1 signaling. Orthologous to human BMT2 (base methyltransferase of 25S rRNA 2 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Samtor in Genome Data Viewer
    Location:
    60D9-60D9; 2-107 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24603572..24604670)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20491095..20492193)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene aarF domain containing kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology. Katarachia SA, et al. Int J Mol Sci, 2023 Jun 2. PMID 37298625, Free PMC Article
    2. Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Tang X, et al. Sci Adv, 2022 Jul. PMID 35776786, Free PMC Article
    3. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Gu X, et al. Science, 2017 Nov 10. PMID 29123071, Free PMC Article
    4. Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number. Gardiol A, et al. Dev Biol, 2014 Aug 15. PMID 24951879, Free PMC Article
    5. An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Liu GY, et al. Nat Commun, 2024 Mar 21. PMID 38514639, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to methionine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-adenosylmethionine sensor upstream of TORC1
    Names
    CG3570-PA
    S-adenosylmethionine sensor upstream of mTORC1
    Samtor-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24603572..24604670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138099.3 → NP_611943.1  S-adenosylmethionine sensor upstream of TORC1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611943.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W138
      Related
      FBpp0072224
      Conserved Domains (1) summary
      cl17173
      Location:186 → 266
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W138.1 Q9W138

    Gene LinkOut

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