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    eIFiso4G2 MIF4G domain-containing protein / MA3 domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816939, updated on 18-Sep-2024

    Summary

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    Official Symbol
    eIFiso4G2
    Official Full Name
    MIF4G domain-containing protein / MA3 domain-containing protein
    Primary source
    TAIR:AT2G24050
    Locus tag
    AT2G24050
    See related
    Araport:AT2G24050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    eukaryotic translation Initiation Factor isoform 4G2; T29E15.25; T29E15_25
    Summary
    Encodes a putative eukaryotic translation initiation factor.
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    Genomic context

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    See eIFiso4G2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (10225225..10228698, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene zinc ion binding / nucleic acid binding protein Neighboring gene Low temperature and salt responsive protein family Neighboring gene Translation initiation factor 3 protein Neighboring gene QWRF motif protein (DUF566) Neighboring gene F-box protein (DUF295)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Eukaryotic Initiation Factor eIFiso4G1 and eIFiso4G2 Are Isoforms Exhibiting Distinct Functional Differences in Supporting Translation in Arabidopsis. Gallie DR. J Biol Chem, 2016 Jan 15. PMID 26578519, Free PMC Article
    2. Deletion of the eIFiso4G subunit of the Arabidopsis eIFiso4F translation initiation complex impairs health and viability. Lellis AD, et al. Plant Mol Biol, 2010 Oct. PMID 20694742, Free PMC Article
    3. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function. Lellis AD, et al. Plant Physiol, 2019 Sep. PMID 31308150, Free PMC Article
    4. Arabidopsis translation initiation factors eIFiso4G1/2 link repression of mRNA cap-binding complex eIFiso4F assembly with RNA-binding protein SOAR1-mediated ABA signaling. Bi C, et al. New Phytol, 2019 Aug. PMID 31050354
    5. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
      Title: eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
    2. SOAR1 inhibits interactions of eIFiso4E, eIF4Es, eIF4A1, eIF4B2 and poly(A)-binding protein PAB6 with eIFiso4G1 and eIFiso4G2, thereby inhibiting eIFiso4F/mixed eIF4F assembly and repressing translation initiation
      Title: Arabidopsis translation initiation factors eIFiso4G1/2 link repression of mRNA cap-binding complex eIFiso4F assembly with RNA-binding protein SOAR1-mediated ABA signaling.
    3. Data (including phylogenetic analysis) suggest that eukaryotic translation initiation factors eIF4G1/eIF(iso)4G1 and eIF4G2/eIF(iso)4G2 exhibit differences in ability to promote translation initiation. [eIF4G2]
      Title: Eukaryotic Initiation Factor eIFiso4G1 and eIFiso4G2 Are Isoforms Exhibiting Distinct Functional Differences in Supporting Translation in Arabidopsis.
    4. Single and double knockout deletions of eIFis4G1 (i4g1) and eIFiso4G2 (i4g2) genes in A. thaliana reduce the amounts of chlorophyll a and b, suggesting a role in the expression of chloroplast proteins. [i4g2] [eIFiso4G2]
      Title: Deletion of the eIFiso4G subunit of the Arabidopsis eIFiso4F translation initiation complex impairs health and viability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127967.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MIF4G domain-containing protein / MA3 domain-containing protein
    NP_179983.1
    • eukaryotic translation Initiation Factor isoform 4G2 (eIFiso4G2); FUNCTIONS IN: RNA binding, binding; INVOLVED IN: translation, RNA metabolic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Initiation factor eIF-4 gamma, MA3 (InterPro:IPR003891), Armadillo-type fold (InterPro:IPR016024), MIF4G-like, type 3 (InterPro:IPR003890), MIF4-like, type 1/2/3 (InterPro:IPR016021); BEST Arabidopsis thaliana protein match is: MIF4G domain-containing protein / MA3 domain-containing protein (TAIR:AT5G57870.2); Has 1738 Blast hits to 1375 proteins in 236 species: Archae - 0; Bacteria - 14; Metazoa - 761; Fungi - 205; Plants - 499; Viruses - 3; Other Eukaryotes - 256 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10225225..10228698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127967.4 → NP_179983.1  MIF4G domain-containing protein / MA3 domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179983.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82233, Q8W4L4
      UniProtKB/TrEMBL
      A0A178VPM7, A0A5S9X0M8, A0A654F0M9
      Conserved Domains (2) summary
      pfam02847
      Location:583 → 695
      MA3; MA3 domain
      pfam02854
      Location:176 → 400
      MIF4G; MIF4G domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82233.1

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