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    Mitofilin mitofilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mitofilinprovided by FlyBase
    Official Full Name
    mitofilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019960
    Locus tag
    Dmel_CG6455
    See related
    AllianceGenome:FB:FBgn0019960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A0A0B4KGN2; CG 6455; CG6455; dIMMT; Dmel\CG6455; dMic60; dMIC60; MIC60; mitofilin
    Summary
    Enables ATP-dependent protein binding activity and protein kinase binding activity. Involved in mitochondrion organization. Located in mitochondrion. Part of MICOS complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mitofilin in Genome Data Viewer
    Location:
    94A1-94A1; 3-74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22019505..22023335, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17845227..17849057, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Testicular haploid expressed gene Neighboring gene Isocitrate dehydrogenase 3b Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene uncharacterized protein Neighboring gene Cytochrome c heme lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure. Tsai PI, et al. Mol Biol Cell, 2017 Nov 15. PMID 28904209, Free PMC Article
    2. Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture. Graham LC, et al. Mol Neurodegener, 2017 Oct 27. PMID 29078798, Free PMC Article
    3. Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. Benincá C, et al. J Med Genet, 2021 Mar. PMID 32439808, Free PMC Article
    4. Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue. Wang LJ, et al. Biol Open, 2020 Dec 2. PMID 33268479, Free PMC Article
    5. Drosophila MIC10b can polymerize into cristae-shaping filaments. Stephan T, et al. Life Sci Alliance, 2024 Apr. PMID 38253420, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitofilin
    Names
    CG6455-PC
    CG6455-PD
    CG6455-PE
    MICOS complex subunit MIC60
    Mitofilin-PC
    Mitofilin-PD
    Mitofilin-PE
    Motor-protein
    dmitofilin
    motor protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22019505..22023335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079720.3 → NP_524444.3  mitofilin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524444.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91928, Q8IN13, Q9V3K0
      UniProtKB/TrEMBL
      A0A0B4KHL7
      Conserved Domains (1) summary
      pfam09731
      Location:68 → 732
      Mitofilin; Mitochondrial inner membrane protein

    2. NM_001275889.1 → NP_001262818.1  mitofilin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91928, Q8IN13, Q9V3K0
      UniProtKB/TrEMBL
      A0A0B4KHL7
      Conserved Domains (1) summary
      pfam09731
      Location:68 → 732
      Mitofilin; Mitochondrial inner membrane protein

    3. NM_001275890.1 → NP_001262819.1  mitofilin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGN2
      Conserved Domains (1) summary
      pfam09731
      Location:68 → 739
      Mitofilin; Mitochondrial inner membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGN2 A0A0B4KGN2
    A0A0B4KHL7 A0A0B4KHL7
    P91928.4 P91928

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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