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    BARD1 breast cancer associated RING 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839329, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BARD1
    Official Full Name
    breast cancer associated RING 1
    Primary source
    TAIR:AT1G04020
    Locus tag
    AT1G04020
    See related
    Araport:AT1G04020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBARD1; breast cancer associated RING 1; F21M11.4; F21M11_4; ROW1
    Summary
    Encodes a protein containing two tandem BRCA1 C-Terminal (BRCT) domains, which function in phosphorylation-dependent protein#Aeiprotein interactions.Loss of function mutations cause defects in meristem organization due to failure to repress WUS. BARD1 binds to WUS promoter and over expression of BARD reduces the extent of WUS expression.
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    Genomic context

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    See BARD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (1036493..1040262)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene phospholipid sterol acyl transferase 1 Neighboring gene eisosome protein Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants. Jiao Y, et al. Sci China Life Sci, 2016 Aug. PMID 27502904
    2. ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells. Zhang Y, et al. Nat Commun, 2015 Jan 29. PMID 25631790, Free PMC Article
    3. A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plants. Reidt W, et al. EMBO J, 2006 Sep 20. PMID 16957774, Free PMC Article
    4. Mutation of Arabidopsis BARD1 causes meristem defects by failing to confine WUSCHEL expression to the organizing center. Han P, et al. Plant Cell, 2008 Jun. PMID 18591352, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings suggest that the study of AtROW1 in plant may provide a model for elucidating the functional mechanism of BARD1 in mammals.
      Title: Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants.
    2. ROW1 is essential for quiescent centre maintenance and for stem cell niche development through the repression of WOX5 in the proximal meristem.
      Title: ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells.
    3. Data suggest that BARD1 regulates shoot apical meristem organization and maintenance by limiting WUS expression to the organizing center.
      Title: Mutation of Arabidopsis BARD1 causes meristem defects by failing to confine WUSCHEL expression to the organizing center.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001331456.1
    NM_202029.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    breast cancer associated RING 1
    NP_001318917.1
    • breast cancer associated RING 1 (BARD1); FUNCTIONS IN: transcription coactivator activity, DNA binding; INVOLVED IN: DNA repair, regulation of meristem structural organization, leaf development; LOCATED IN: intracellular; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, PHD-type (InterPro:IPR001965), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: breast cancer susceptibility1 (TAIR:AT4G21070.1); Has 5889 Blast hits to 5527 proteins in 313 species: Archae - 0; Bacteria - 10; Metazoa - 4435; Fungi - 374; Plants - 570; Viruses - 11; Other Eukaryotes - 489 (source: NCBI BLink).
    NP_973758.2
    • breast cancer associated RING 1 (BARD1); FUNCTIONS IN: transcription coactivator activity, DNA binding; INVOLVED IN: DNA repair, regulation of meristem structural organization, leaf development; LOCATED IN: intracellular; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, PHD-type (InterPro:IPR001965), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: breast cancer susceptibility1 (TAIR:AT4G21070.1); Has 6045 Blast hits to 5706 proteins in 320 species: Archae - 0; Bacteria - 47; Metazoa - 4577; Fungi - 362; Plants - 542; Viruses - 11; Other Eukaryotes - 506 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1036493..1040262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331456.1 → NP_001318917.1  breast cancer associated RING 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5A7D6, B5A7D7, F4I443, Q9ZWC2
      UniProtKB/TrEMBL
      A0A178W540, A0A2H1ZEA6, A0A384KH31
      Conserved Domains (4) summary
      TIGR00599
      Location:35 → 262
      rad18; DNA repair protein rad18
      cd15571
      Location:359 → 449
      ePHD; Extended plant homeodomain (PHD) finger, characterized by Cys2HisCys5HisCys2His
      cd17720
      Location:601 → 707
      BRCT_Bard1_rpt2; second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins
      cd17734
      Location:490 → 569
      BRCT_Bard1_rpt1; first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

    2. NM_202029.2 → NP_973758.2  breast cancer associated RING 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973758.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5A7D6, B5A7D7, F4I443, Q9ZWC2
      UniProtKB/TrEMBL
      F4I442
      Conserved Domains (5) summary
      smart00292
      Location:599 → 703
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:491 → 564
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      TIGR00599
      Location:35 → 262
      rad18; DNA repair protein rad18
      cd15571
      Location:359 → 449
      ePHD; Extended plant homeodomain (PHD) finger, characterized by Cys2HisCys5HisCys2His
      pfam13639
      Location:34 → 63
      zf-RING_2; Ring finger domain
    Nucleotide Protein
    Heading Accession and Version

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