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    p47 p47 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    p47provided by FlyBase
    Official Full Name
    p47provided by FlyBase
    Primary source
    FLYBASE:FBgn0033179
    Locus tag
    Dmel_CG11139
    See related
    AllianceGenome:FB:FBgn0033179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.216; CG11139; Dmel\CG11139; dp47; P47
    Summary
    Predicted to enable ubiquitin binding activity. Involved in nuclear membrane reassembly and rhabdomere development. Located in cytoplasm and nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to several human genes including NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See p47 in Genome Data Viewer
    Location:
    43C3-43C4; 2-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7465018..7466759, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3352523..3354264, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aldehyde dehydrogenase type III Neighboring gene wech

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of the p47 (L.3.2) mutation in Drosophilamelanogaster. Cordes CN, et al. MicroPubl Biol, 2023. PMID 37799208, Free PMC Article
    2. RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. Wójcik C, et al. J Cell Sci, 2004 Jan 15. PMID 14657277
    3. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    4. Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis. Sang TK, et al. Development, 2002 Jan. PMID 11782408
    5. Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation. Zhang Z, et al. Dev Cell, 2013 Jun 24. PMID 23747190

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear membrane reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear membrane reassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    p47
    Names
    CG11139-PA
    p47 a
    p47-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7465018..7466759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136440.6 → NP_610284.1  p47 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Z3
      Related
      FBpp0088069
      Conserved Domains (3) summary
      cd01770
      Location:329 → 407
      p47_UBX; p47-like ubiquitin domain
      smart00553
      Location:211 → 300
      SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
      cd14672
      Location:6 → 42
      UBA_ceTYDP2_like; UBA-like domain found in Caenorhabditis elegans tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3Z3 Q7K3Z3

    Gene LinkOut

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