EIF4A-2 eif4a-2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: EIF4A-2
Official Full Name: eif4a-2
Primary source: TAIR:AT1G54270
Locus tag: AT1G54270
See related: Araport:AT1G54270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: eif4a-2; F20D21.9; F20D21_9
Summary: member of eIF4A - eukaryotic initiation factor 4A
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Genomic context

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See EIF4A-2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (20259547..20262266)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin-dependent kinase A (CDKA) phosphorylates eukaryotic initiation factor 4A (eIF4A)eIF4A1 and eIF4A2 on a conserved threonine residue (threonine-164) within the RNA-binding motif.
Title: eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001198291.2

Supported by ESTs:

NM_104305.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: eif4a-2

NP_001185220.1

eif4a-2 (EIF4A-2); CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 4A1 (TAIR:AT3G13920.4).

NP_175829.1

eif4a-2 (EIF4A-2); FUNCTIONS IN: ATP-dependent helicase activity, translation initiation factor activity; INVOLVED IN: response to cadmium ion; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 4A1 (TAIR:AT3G13920.1); Has 47858 Blast hits to 47246 proteins in 3099 species: Archae - 743; Bacteria - 25967; Metazoa - 6043; Fungi - 4764; Plants - 2602; Viruses - 17; Other Eukaryotes - 7722 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

20259547..20262266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104305.4 → NP_175829.1 eif4a-2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175829.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41377, Q0WWK5

UniProtKB/TrEMBL

A0A178W4U1, A0A5S9WPV0, A0A5S9XC50

Conserved Domains (1) summary

PTZ00424
Location:26 → 412

PTZ00424; helicase 45; Provisional
NM_001198291.2 → NP_001185220.1 eif4a-2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185220.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XC50, F4HV96

Conserved Domains (3) summary

PTZ00424
Location:26 → 407

PTZ00424; helicase 45; Provisional

cd00079
Location:247 → 376

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:41 → 236

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...