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    ICR1 interactor of constitutive active rops 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838284, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ICR1
    Official Full Name
    interactor of constitutive active rops 1
    Primary source
    TAIR:AT1G17140
    Locus tag
    AT1G17140
    See related
    Araport:AT1G17140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F20D23.32; interactor of constitutive active rops 1; RIP1; ROP INTERACTIVE PARTNER 1
    Summary
    Encodes a ROP/RAC effector, designated interactor of constitutive active ROPs 1 (ICR1), that interacts with GTP-bound ROPs. ICR1 is a scaffold mediating formation of protein complexes that are required for cell polarity. ICR1 is comprised of coiled-coil domains and forms complexes with itself and the exocyst vesicle-tethering complex subunit SEC3.
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    Genomic context

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    See ICR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (5856573..5858550, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cationic amino acid transporter 8 Neighboring gene coiled-coil protein (DUF572) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein Neighboring gene VQ motif-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bimodal regulation of ICR1 levels generates self-organizing auxin distribution. Hazak O, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25468974, Free PMC Article
    2. A rho scaffold integrates the secretory system with feedback mechanisms in regulation of auxin distribution. Hazak O, et al. PLoS Biol, 2010 Jan 19. PMID 20098722, Free PMC Article
    3. A Novel ROP/RAC effector links cell polarity, root-meristem maintenance, and vesicle trafficking. Lavy M, et al. Curr Biol, 2007 Jun 5. PMID 17493810
    4. MEF10 is required for RNA editing at nad2-842 in mitochondria of Arabidopsis thaliana and interacts with MORF8. Härtel B, et al. Plant Mol Biol, 2013 Mar. PMID 23288601
    5. Novel coiled-coil proteins regulate exocyst association with cortical microtubules in xylem cells via the conserved oligomeric golgi-complex 2 protein. Oda Y, et al. Plant Cell Physiol, 2015 Feb. PMID 25541219

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bimodal regulation of ICR1 levels generates self-organizing auxin distribution.
      Title: Bimodal regulation of ICR1 levels generates self-organizing auxin distribution.
    2. RIP1 is involved in the positive feedback regulation of ROP1 localization to the plasma membrane, leading to the establishment of a polar site for pollen germination and pollen tube growth. [RIP1]
      Title: RIP1 (ROP Interactive Partner 1)/ICR1 marks pollen germination sites and may act in the ROP1 pathway in the control of polarized pollen growth.
    3. ICR1 is part of an auxin regulated positive feedback loop realized by a unique integration of auxin-dependent transcriptional regulation into ROP-mediated modulation of cell polarity.
      Title: A rho scaffold integrates the secretory system with feedback mechanisms in regulation of auxin distribution.
    4. ICR1 interacts with GTP-bound ROPs and is required for cell polarity and differentiation.
      Title: A Novel ROP/RAC effector links cell polarity, root-meristem maintenance, and vesicle trafficking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101574.3
    NM_202119.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in pollen tube tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interactor of constitutive active rops 1
    NP_564015.1
    • interactor of constitutive active rops 1 (ICR1); BEST Arabidopsis thaliana protein match is: ROP interactive partner 2 (TAIR:AT1G78430.1); Has 53861 Blast hits to 29615 proteins in 2229 species: Archae - 901; Bacteria - 7093; Metazoa - 25838; Fungi - 5211; Plants - 3173; Viruses - 136; Other Eukaryotes - 11509 (source: NCBI BLink).
    NP_973848.1
    • interactor of constitutive active rops 1 (ICR1); BEST Arabidopsis thaliana protein match is: ROP interactive partner 2 (TAIR:AT1G78430.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5856573..5858550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202119.2 → NP_973848.1  interactor of constitutive active rops 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973848.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WP02, Q29Q29, Q8LE98
      UniProtKB/TrEMBL
      A0A178W8G4, A0A5S9USZ0
      Conserved Domains (1) summary
      COG1196
      Location:61 → 268
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_101574.3 → NP_564015.1  interactor of constitutive active rops 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WP02, Q29Q29, Q8LE98
      UniProtKB/TrEMBL
      A0A178W8G4, A0A5S9USZ0
      Conserved Domains (1) summary
      COG1196
      Location:61 → 268
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LE98.1

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