pfkB-like carbohydrate kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: pfkB-like carbohydrate kinase family protein
Primary source: TAIR:AT1G17160
Locus tag: AT1G17160
See related: Araport:AT1G17160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F20D23.14; F20D23_14
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (5867535..5869436)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structural data combined with activity analyses of mutants ATP-dependent ribokinase (RBSK) allowed assignment of functional roles for the active site residues..
Title: Crystal structure and mutational analyses of ribokinase from Arabidopsis thaliana.
At1g17160 (AtRBSK). AtRBSK is more similar to predicted RBSKs from other plant species and known mammalian and prokaryotic RBSK than to all other PfkB proteins in Arabidopsis AtRBSK contains a predicted chloroplast transit peptide, and we confirmed plastid localization using AtRBSK fused to YFP.
Title: Identification of the Plant Ribokinase and Discovery of a Role for Arabidopsis Ribokinase in Nucleoside Metabolism.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001084082.2

Supported by ESTs:

NM_101577.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ribokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribokinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-ribose catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleoside metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in plastid nucleoid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pfkB-like carbohydrate kinase family protein

NP_001077551.1

pfkB-like carbohydrate kinase family protein; FUNCTIONS IN: kinase activity, ribokinase activity; INVOLVED IN: D-ribose metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611), Ribokinase (InterPro:IPR002139), Carbohydrate/puine kinase, PfkB, conserved site (InterPro:IPR002173); BEST Arabidopsis thaliana protein match is: pfkB-like carbohydrate kinase family protein (TAIR:AT1G06030.1); Has 20525 Blast hits to 20525 proteins in 2560 species: Archae - 370; Bacteria - 15982; Metazoa - 398; Fungi - 241; Plants - 483; Viruses - 0; Other Eukaryotes - 3051 (source: NCBI BLink).

NP_173159.1

pfkB-like carbohydrate kinase family protein; FUNCTIONS IN: kinase activity, ribokinase activity; INVOLVED IN: D-ribose metabolic process, D-ribose catabolic process; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611), Ribokinase (InterPro:IPR002139), Carbohydrate/puine kinase, PfkB, conserved site (InterPro:IPR002173); BEST Arabidopsis thaliana protein match is: pfkB-like carbohydrate kinase family protein (TAIR:AT1G06030.1); Has 24314 Blast hits to 24305 proteins in 2661 species: Archae - 422; Bacteria - 18834; Metazoa - 425; Fungi - 293; Plants - 520; Viruses - 0; Other Eukaryotes - 3820 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

5867535..5869436

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101577.5 → NP_173159.1 pfkB-like carbohydrate kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173159.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1A6H3, Q9SHH5

UniProtKB/TrEMBL

A0A178WMA8, A0A5S9UTV8

Conserved Domains (1) summary

cd01174
Location:70 → 367

ribokinase; Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides ...
NM_001084082.2 → NP_001077551.1 pfkB-like carbohydrate kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077551.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WMA8, A0A5S9UTV8, A8MQX7

Conserved Domains (1) summary

cd01174
Location:70 → 348

ribokinase; Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides ...