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    NRAMP1 natural resistance-associated macrophage protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844422, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRAMP1
    Official Full Name
    natural resistance-associated macrophage protein 1
    Primary source
    TAIR:AT1G80830
    Locus tag
    AT1G80830
    See related
    Araport:AT1G80830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNRAMP1; F23A5.18; F23A5_18; natural resistance-associated macrophage protein 1; PMIT1
    Summary
    Thought to be involved in iron homeostasis. Induced in leaves in response to iron deficiency. Transgenic plants accumulate toxic levels of iron. Gene complements yeast iron uptake mutants.
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    Genomic context

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    See NRAMP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (30372668..30376072, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene cinnamoyl coa reductase Neighboring gene WRKY DNA-binding protein 40 Neighboring gene DNA glycosylase superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved histidine of metal transporter AtNRAMP1 is crucial for optimal plant growth under manganese deficiency at chilling temperatures. Ihnatowicz A, et al. New Phytol, 2014 Jun. PMID 24571269
    2. High-affinity manganese uptake by the metal transporter NRAMP1 is essential for Arabidopsis growth in low manganese conditions. Cailliatte R, et al. Plant Cell, 2010 Mar. PMID 20228245, Free PMC Article
    3. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Thomine S, et al. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781110, Free PMC Article
    4. Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis. Kosuth T, et al. FEBS Lett, 2023 Aug. PMID 37501385
    5. Phosphatidylinositol 3-phosphate-binding protein AtPH1 controls the localization of the metal transporter NRAMP1 in Arabidopsis. Agorio A, et al. Proc Natl Acad Sci U S A, 2017 Apr 18. PMID 28373552, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
      Title: Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
    2. CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
      Title: CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
    3. Ca(2+)-dependent phosphorylation of NRAMP1 by CPK21 and CPK23 facilitates manganese uptake and homeostasis in Arabidopsis.
      Title: Ca(2+)-dependent phosphorylation of NRAMP1 by CPK21 and CPK23 facilitates manganese uptake and homeostasis in Arabidopsis.
    4. Data suggest that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions.
      Title: The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision.
    5. show that loss of AtPH1 function leads to the mislocalization of the metal uptake transporter NRAMP1 to the vacuole, providing a rationale for the reversion of nramp3nramp4 phenotypes
      Title: Phosphatidylinositol 3-phosphate-binding protein AtPH1 controls the localization of the metal transporter NRAMP1 in Arabidopsis.
    6. The NRAMP-specific highly conserved histidine was shown to be crucial for plant performance.
      Title: Conserved histidine of metal transporter AtNRAMP1 is crucial for optimal plant growth under manganese deficiency at chilling temperatures.
    7. NRAMP1 functions as a physiological Mn transporter in Arabidopsis and that it is required for high-affinity Mn uptake into the root in conditions of low Mn availability.
      Title: High-affinity manganese uptake by the metal transporter NRAMP1 is essential for Arabidopsis growth in low manganese conditions.
    8. Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease.
      Title: Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335016.1
    NM_106731.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cadmium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inorganic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cadmium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular monoatomic cation homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lead ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in manganese ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within metal ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    natural resistance-associated macrophage protein 1
    NP_178198.1
    • natural resistance-associated macrophage protein 1 (NRAMP1); CONTAINS InterPro DOMAIN/s: Natural resistance-associated macrophage protein (InterPro:IPR001046); BEST Arabidopsis thaliana protein match is: NRAMP metal ion transporter 6 (TAIR:AT1G15960.1); Has 5566 Blast hits to 5511 proteins in 1695 species: Archae - 118; Bacteria - 4154; Metazoa - 357; Fungi - 273; Plants - 337; Viruses - 0; Other Eukaryotes - 327 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30372668..30376072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106731.3 → NP_178198.1  natural resistance-associated macrophage protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JPT0, Q8L7N5, Q8LCS7, Q9SAH8, Q9SP94
      UniProtKB/TrEMBL
      A0A178W717, A0A5S9WW62, A0A654ESA4
      Conserved Domains (1) summary
      PRK00701
      Location:41 → 454
      PRK00701; divalent metal cation transporter MntH

    2. NM_001335016.1 → NP_001321606.1  natural resistance-associated macrophage protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JPT0, Q8L7N5, Q8LCS7, Q9SAH8, Q9SP94
      UniProtKB/TrEMBL
      A0A178W717, A0A5S9WW62, A0A654ESA4
      Conserved Domains (1) summary
      PRK00701
      Location:41 → 454
      PRK00701; divalent metal cation transporter MntH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SAH8.1

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