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    IMS1 2-isopropylmalate synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843742, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IMS1
    Official Full Name
    2-isopropylmalate synthase 1
    Primary source
    TAIR:AT1G74040
    Locus tag
    AT1G74040
    See related
    Araport:AT1G74040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    2-isopropylmalate synthase 1; 2-ISOPROPYLMALATE SYNTHASE 1; F2P9.9; F2P9_9; IPMS2; ISOPROPYLMALATE SYNTHASE 2; MAML-3; SOPROPYLMALATE SYNTHASE 2
    Summary
    Encodes an active Arabidopsis isopropylmalate synthase IPMS2. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS2 can be compensated by a second isopropylmalate synthase gene IPMS1 (At1g18500).
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    Genomic context

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    See IMS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (27842109..27845782)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene strictosidine synthase 2 Neighboring gene uncharacterized protein Neighboring gene enolase 1 Neighboring gene tetraspanin-17 protein Neighboring gene Ribosomal protein L6 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis. de Kraker JW, et al. Plant Cell, 2011 Jan. PMID 21205930, Free PMC Article
    2. Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine. de Kraker JW, et al. Plant Physiol, 2007 Feb. PMID 17189332, Free PMC Article
    3. Isolation and expression analysis of the isopropylmalate synthase gene family of Arabidopsis thaliana. Junk DJ, et al. J Exp Bot, 2002 Dec. PMID 12432038
    4. Glucosinolate and amino acid biosynthesis in Arabidopsis. Field B, et al. Plant Physiol, 2004 Jun. PMID 15155874, Free PMC Article
    5. A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network. Xing A, et al. Plant Cell, 2017 Jun. PMID 28522547, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the C-terminal domain of IPMS increases MAM activity.
      Title: From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis.
    2. Two isopropylmalate synthase genes from A. thaliana are described.
      Title: Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334624.1
    NM_001334625.1
    NM_106063.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-isopropylmalate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-isopropylmalate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-isopropylmalate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 2-isopropylmalate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-leucine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-leucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-leucine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 

    General protein information

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    Preferred Names
    2-isopropylmalate synthase 1
    NP_177544.1
    • 2-isopropylmalate synthase 1 (IMS1); FUNCTIONS IN: 2-isopropylmalate synthase activity; INVOLVED IN: leucine biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (InterPro:IPR013709), Pyruvate carboxyltransferase (InterPro:IPR000891), Bacterial 2-isopropylmalate synthase (InterPro:IPR005671); BEST Arabidopsis thaliana protein match is: methylthioalkylmalate synthase-like 4 (TAIR:AT1G18500.1); Has 16891 Blast hits to 16883 proteins in 2449 species: Archae - 499; Bacteria - 8886; Metazoa - 193; Fungi - 474; Plants - 279; Viruses - 0; Other Eukaryotes - 6560 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27842109..27845782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106063.3 → NP_177544.1  2-isopropylmalate synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWX8, Q9C550
      UniProtKB/TrEMBL
      A0A178WEK1, A0A5S9WU76
      Conserved Domains (3) summary
      cd07940
      Location:89 → 368
      DRE_TIM_IPMS; 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain
      smart00917
      Location:466 → 609
      LeuA_dimer; LeuA allosteric (dimerisation) domain
      PLN02321
      Location:5 → 631
      PLN02321; 2-isopropylmalate synthase

    2. NM_001334624.1 → NP_001322763.1  2-isopropylmalate synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WEK1, A0A1P8AUZ8, A0A5S9WU76

    3. NM_001334625.1 → NP_001322762.1  2-isopropylmalate synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AV04
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C550.1

    Gene LinkOut

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