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    HY2 phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820069, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HY2
    Official Full Name
    phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2)
    Primary source
    TAIR:AT3G09150
    Locus tag
    AT3G09150
    See related
    Araport:AT3G09150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS ELONGATED HYPOCOTYL 2; ATHY2; ELONGATED HYPOCOTYL 2; GENOMES UNCOUPLED 3; GUN3; PHYTOCHROMOBILIN SYNTHASE
    Summary
    Required for biosynthesis of the tetrapyrrole phytochrome chromophore phytochromobilin. Encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase. It is necessary for coupling the expression of some nuclear genes to the functional state of the chloroplast.
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    Genomic context

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    See HY2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (2803528..2805922)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hypothetical protein (DUF674) Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis HY2 Gene Acts as a Positive Regulator of NaCl Signaling during Seed Germination. Piao M, et al. Int J Mol Sci, 2021 Aug 20. PMID 34445714, Free PMC Article
    2. Targeted Ds-tagging strategy generates high allelic diversity at the Arabidopsis HY2 locus. Creff A, et al. Plant Mol Biol, 2006 Jul. PMID 16897478
    3. The Arabidopsis HY2 gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase. Kohchi T, et al. Plant Cell, 2001 Feb. PMID 11226195, Free PMC Article
    4. Electrostatic interaction of phytochromobilin synthase and ferredoxin for biosynthesis of phytochrome chromophore. Chiu FY, et al. J Biol Chem, 2010 Feb 12. PMID 19996315, Free PMC Article
    5. The Arabidopsis ELF3 gene regulates vegetative photomorphogenesis and the photoperiodic induction of flowering. Zagotta MT, et al. Plant J, 1996 Oct. PMID 8893545

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis HY2 Gene Acts as a Positive Regulator of NaCl Signaling during Seed Germination.
      Title: The Arabidopsis HY2 Gene Acts as a Positive Regulator of NaCl Signaling during Seed Germination.
    2. Study found that one of the six Arabidopsis Fds, AtFd2, was the preferred electron donor for HY2.
      Title: Electrostatic interaction of phytochromobilin synthase and ferredoxin for biosynthesis of phytochrome chromophore.
    3. The use of a maize Ds element in direct tagging of HY2 in A. thaliana is reported.
      Title: Targeted Ds-tagging strategy generates high allelic diversity at the Arabidopsis HY2 locus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337803.1
    NM_111750.4
    NM_180665.1
    NM_202535.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phytochromobilin:ferredoxin oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phytochromobilin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phytochromobilin biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2)
    NP_566344.2
    • ELONGATED HYPOCOTYL 2 (HY2); CONTAINS InterPro DOMAIN/s: Ferredoxin-dependent bilin reductase (InterPro:IPR009249); Has 407 Blast hits to 407 proteins in 62 species: Archae - 0; Bacteria - 187; Metazoa - 0; Fungi - 0; Plants - 48; Viruses - 0; Other Eukaryotes - 172 (source: NCBI BLink).
    NP_850996.1
    • ELONGATED HYPOCOTYL 2 (HY2); CONTAINS InterPro DOMAIN/s: Ferredoxin-dependent bilin reductase (InterPro:IPR009249); Has 403 Blast hits to 403 proteins in 61 species: Archae - 0; Bacteria - 184; Metazoa - 0; Fungi - 0; Plants - 48; Viruses - 0; Other Eukaryotes - 171 (source: NCBI BLink).
    NP_974264.1
    • ELONGATED HYPOCOTYL 2 (HY2); CONTAINS InterPro DOMAIN/s: Ferredoxin-dependent bilin reductase (InterPro:IPR009249); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2803528..2805922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111750.4 → NP_566344.2  phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566344.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L8Q6, Q9SR43, Q9SS72
      UniProtKB/TrEMBL
      A0A178VF68
      Conserved Domains (1) summary
      pfam05996
      Location:55 → 281
      Fe_bilin_red; Ferredoxin-dependent bilin reductase

    2. NM_001337803.1 → NP_001326171.1  phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VF68, A0A1I9LNG4

    3. NM_180665.1 → NP_850996.1  phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850996.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VF68
      Conserved Domains (1) summary
      pfam05996
      Location:56 → 279
      Fe_bilin_red; Ferredoxin-dependent bilin reductase

    4. NM_202535.1 → NP_974264.1  phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IZU7
      Conserved Domains (1) summary
      pfam05996
      Location:1 → 202
      Fe_bilin_red; Ferredoxin-dependent bilin reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SR43.1

    Gene LinkOut

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