MSH5 MUTS-homologue 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MSH5
Official Full Name: MUTS-homologue 5
Primary source: TAIR:AT3G20475
Locus tag: AT3G20475
See related: Araport:AT3G20475
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMSH5; MUTS-homologue 5; MUTS-HOMOLOGUE 5
Summary: Encodes MSH5, a homologue of the MutS-homolog family of genes required for normal levels of recombination in budding yeast, mouse and Caenorhabditis elegans. Involved in meiotic recombination. Required for the formation of Class I interference-sensitive crossovers. Transcripts of AtMSH5 are specific to reproductive tissues and expression of the protein is abundant during prophase I of meiosis. Involved in meiotic recombination. Required for the formation of Class I interference-sensitive crossovers.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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required for the formation of class I interference-sensitive crossovers
Title: AtMSH5 partners AtMSH4 in the class I meiotic crossover pathway in Arabidopsis thaliana, but is not required for synapsis.
Data indicate that AtMSH5 promotes homologous recombination through facilitating chiasma formation during prophase I in Arabidopsis.
Title: The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis.

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NM_112939.4

Function	Evidence Code	Pubs
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic mismatch repair involved in reciprocal meiotic recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in mismatch repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_188683.3

MUTS-homologue 5 (MSH5); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, chiasma assembly, reciprocal meiotic recombination; LOCATED IN: condensed nuclear chromosome; EXPRESSED IN: male gametophyte, flower, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, IL.00 inflorescence just visible; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432); BEST Arabidopsis thaliana protein match is: MUTS homolog 2 (TAIR:AT3G18524.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

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