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    CLE41 CLAVATA3/ESR-RELATED 41 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822075, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLE41
    Official Full Name
    CLAVATA3/ESR-RELATED 41
    Primary source
    TAIR:AT3G24770
    Locus tag
    AT3G24770
    See related
    Araport:AT3G24770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLAVATA3/ESR-RELATED 41
    Summary
    Belongs to a large gene family, called CLE for CLAVATA3/ESR-related, encoding small peptides with conserved carboxyl termini. The C-terminal 12 amino acid sequence of CLE41 is identical to that of a dodeca peptide (TDIF, tracheary element differentiation inhibitory factor) isolated from Arabidopsis and functions as a suppressor of plant stem cell differentiation. TDIF sequence is also identical to the C-terminal 12 amino acids of CLE44 (At4g13195). The protein is expressed in the vascular system and is involved in axillary bud formation.
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    Genomic context

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    See CLE41 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (9046293..9047463)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene miscRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs. Zhang H, et al. Cell Res, 2016 May. PMID 27055373, Free PMC Article
    2. Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division. Etchells JP, et al. Curr Biol, 2015 Apr 20. PMID 25866390, Free PMC Article
    3. Dodeca-CLE peptides as suppressors of plant stem cell differentiation. Ito Y, et al. Science, 2006 Aug 11. PMID 16902140
    4. The PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division. Etchells JP, et al. Development, 2010 Mar. PMID 20147378
    5. Non-cell-autonomous control of vascular stem cell fate by a CLE peptide/receptor system. Hirakawa Y, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18812507, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data provide a structural template for understanding the recognition mechanism of CLE peptides by their receptors. The crystal structure of TDIF in complex with its receptor PXY, a leucine-rich repeat receptor kinase (LRR-RK), is reported.[CLE41]
      Title: Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs.
    2. Data demonstrate that the PXY-CLE pathway has evolved to regulate secondary growth and manipulating this pathway can result in dramatically increased tree growth and productivity.
      Title: Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division.
    3. PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division.
      Title: The PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division.
    Submit: New GeneRIF Correction

    General gene information

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    NM_113389.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axillary shoot meristem initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell signaling involved in cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maintenance of root meristem identity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phloem development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in procambium histogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary shoot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xylem development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apoplast ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CLAVATA3/ESR-RELATED 41
    NP_566754.1
    • CLAVATA3/ESR-RELATED 41 (CLE41); BEST Arabidopsis thaliana protein match is: CLAVATA3/ESR-RELATED 44 (TAIR:AT4G13195.1); Has 25 Blast hits to 25 proteins in 7 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 25; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9046293..9047463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113389.1 → NP_566754.1  CLAVATA3/ESR-RELATED 41 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84W98, Q8LB23
      UniProtKB/TrEMBL
      A0A178VDH8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84W98.1

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