TPR2 TOPLESS-related 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TPR2
Official Full Name: TOPLESS-related 2
Primary source: TAIR:AT3G16830
Locus tag: AT3G16830
See related: Araport:AT3G16830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: TOPLESS-related 2
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Genomic context

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See TPR2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 25

Sequence:: Chromosome: 3; NC_003074.8 (5731519..5737854)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Opposing functions of the plant TOPLESS gene family during SNC1-mediated autoimmunity.
Title: Opposing functions of the plant TOPLESS gene family during SNC1-mediated autoimmunity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112557.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within primary shoot apical meristem specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: TOPLESS-related 2

NP_188306.2

TOPLESS-related 2 (TPR2); FUNCTIONS IN: protein binding; INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: TOPLESS-related 3 (TAIR:AT5G27030.1); Has 13436 Blast hits to 8919 proteins in 512 species: Archae - 16; Bacteria - 3246; Metazoa - 4126; Fungi - 2976; Plants - 1389; Viruses - 0; Other Eukaryotes - 1683 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

5731519..5737854

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112557.4 → NP_188306.2 TOPLESS-related 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188306.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LRZ0

UniProtKB/TrEMBL

A0A178VCB7, A0A5S9XCV0, A0A7G2EIV0

Conserved Domains (5) summary

smart00667
Location:4 → 34

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:34 → 92

CTLH; C-terminal to LisH motif

sd00039
Location:352 → 407

7WD40; WD40 repeat [structural motif]

pfam10607
Location:71 → 135

CLTH; CTLH/CRA C-terminal to LisH motif domain

cl29593
Location:348 → 657

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...