GR1 glutathione-disulfide reductase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GR1
Official Full Name: glutathione-disulfide reductase
Primary source: TAIR:AT3G24170
Locus tag: AT3G24170
See related: Araport:AT3G24170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGR1; glutathione-disulfide reductase
Summary: Encodes a cytosolic glutathione reductase.
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Genomic context

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See GR1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 17

Sequence:: Chromosome: 3; NC_003074.8 (8729354..8734624, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GR1 and NTRA involved in pollen tube growth in the stigma of Arabidopsis.
Title: GR1 and NTRA involved in pollen tube growth in the stigma of Arabidopsis.
Evidence of a significant role of glutathione reductase in the sulfur assimilation pathway.
Title: Evidence of a significant role of glutathione reductase in the sulfur assimilation pathway.
overexpression led to high GSH, suppression of reactive oxygen and carbonyl species generation, and enhanced aluminum tolerance
Title: High level of reduced glutathione contributes to detoxification of lipid peroxide-derived reactive carbonyl species in transgenic Arabidopsis overexpressing glutathione reductase under aluminum stress.
Ozone responses of mutants for cytosolic NADP-isocitrate dehydrogenase (icdh) and glutathione reductase 1 (gr1) were analysed.
Title: Analysis of cytosolic isocitrate dehydrogenase and glutathione reductase 1 in photoperiod-influenced responses to ozone using Arabidopsis knockout mutants.
GR1 plays a crucial role in daylength-dependent redox signaling.
Title: Arabidopsis GLUTATHIONE REDUCTASE1 plays a crucial role in leaf responses to intracellular hydrogen peroxide and in ensuring appropriate gene expression through both salicylic acid and jasmonic acid signaling pathways.
The results demonstrate TRXh3 in conjunction with NTRA as a GR-independent mechanism of GSSG reduction capable of partially complementing gr1 mutants.
Title: The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001035679.2

Supported by ESTs:

NM_001125216.1

Supported by ESTs:

NM_113322.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables glutathione-disulfide reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pollen tube growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in peroxisome	HDA more info	PubMed

General protein information

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Preferred Names: glutathione-disulfide reductase

NP_001030756.2

glutathione-disulfide reductase (GR1); FUNCTIONS IN: glutathione-disulfide reductase activity, NADP or NADPH binding, oxidoreductase activity, FAD binding; INVOLVED IN: oxidation reduction, glutathione metabolic process, cell redox homeostasis; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Glutathione-disulphide reductase (InterPro:IPR006324), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: glutathione reductase (TAIR:AT3G54660.1); Has 36321 Blast hits to 36258 proteins in 3163 species: Archae - 851; Bacteria - 26543; Metazoa - 909; Fungi - 471; Plants - 667; Viruses - 0; Other Eukaryotes - 6880 (source: NCBI BLink).

NP_001118688.1

glutathione-disulfide reductase (GR1); FUNCTIONS IN: NADP or NADPH binding, glutathione-disulfide reductase activity, oxidoreductase activity, FAD binding; INVOLVED IN: oxidation reduction, glutathione metabolic process, cell redox homeostasis; LOCATED IN: peroxisome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Glutathione-disulphide reductase (InterPro:IPR006324), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: glutathione reductase (TAIR:AT3G54660.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_189059.1

glutathione-disulfide reductase (GR1); FUNCTIONS IN: NADP or NADPH binding, glutathione-disulfide reductase activity, oxidoreductase activity, FAD binding; INVOLVED IN: oxidation reduction, glutathione metabolic process, cell redox homeostasis; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Glutathione-disulphide reductase (InterPro:IPR006324), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: glutathione reductase (TAIR:AT3G54660.1); Has 36408 Blast hits to 36344 proteins in 3180 species: Archae - 854; Bacteria - 26624; Metazoa - 911; Fungi - 472; Plants - 667; Viruses - 0; Other Eukaryotes - 6880 (source: NCBI BLink).