RACK1B_AT receptor for activated C kinase 1B [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RACK1B_AT
Official Full Name: receptor for activated C kinase 1B
Primary source: TAIR:AT1G48630
Locus tag: AT1G48630
See related: Araport:AT1G48630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F11I4.18; F11I4_18; RACK1B; receptor for activated C kinase 1B
Summary: Encodes a protein with similarity to mammalian RACKs. RACKs function to shuttle activated protein kinase C to different subcellular sites and may also function as a scaffold through physical interactions with other proteins. RACK1B has no phenotype on its own and probably acts redundantly with RACK1A and RACK1C.
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Genomic context

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See RACK1B_AT in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 2

Sequence:: Chromosome: 1; NC_003070.9 (17981636..17983377, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study illustrates that protein stability controlled by dynamic post-transcriptional modification is a critical regulatory mechanism for receptor for activated c kinase 1B which functions as scaffold protein for RAP2.6 in ABA signaling.
Title: Sumoylation stabilizes RACK1B and enhance its interaction with RAP2.6 in the abscisic acid response.
RACK1 may be required for normal production of 60S and 80S ribosomes and that its action in these processes may be regulated by abscissic acid. [RACK1B]
Title: Involvement of Arabidopsis RACK1 in protein translation and its regulation by abscisic acid.
RACK1 genes act redundantly to negatively regulate abscisic acid responses during seed germination and early seedling development.
Title: RACK1 is a negative regulator of ABA responses in Arabidopsis.
RACK1B (At1g48630) is functionally equivalent to RACK1A, and is positively regulated by other RACK1 genes.
Title: RACK1 genes regulate plant development with unequal genetic redundancy in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_103759.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables MAP-kinase scaffold activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to abscisic acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within root development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within seed germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within shoot system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor for activated C kinase 1B

NP_175296.1

receptor for activated C kinase 1B (RACK1B_AT); FUNCTIONS IN: nucleotide binding; INVOLVED IN: shoot development, root development; LOCATED IN: cytosolic ribosome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: receptor for activated C kinase 1C (TAIR:AT3G18130.1); Has 89864 Blast hits to 37441 proteins in 950 species: Archae - 80; Bacteria - 10219; Metazoa - 35696; Fungi - 20361; Plants - 11462; Viruses - 9; Other Eukaryotes - 12037 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

17981636..17983377 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_103759.5 → NP_175296.1 receptor for activated C kinase 1B [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175296.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q42130, Q8LAF2, Q9C4Z6

UniProtKB/TrEMBL

A0A178V9J1, A0A178W908, A0A5S9WN01, A0A5S9XER9

Conserved Domains (2) summary

cd00200
Location:6 → 321

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:18 → 61

7WD40; WD40 repeat [structural motif]