GLB1 nitrogen regulatory P-II-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GLB1
Official Full Name: nitrogen regulatory P-II-like protein
Primary source: TAIR:AT4G01900
Locus tag: AT4G01900
See related: Araport:AT4G01900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: GLNB1 homolog; PII; PII PROTEIN; T7B11.16; T7B11_16
Summary: encodes a PII protein that may function as part of a signal transduction network involved in perceiving the status of carbon and organic nitrogen. Forms a protein complex with N-acetylglutamate kinase and regulates the kinase activity by relieving the feedback inhibition of the kinase by arginine. Regulates acetyl-CoA carboxylase activity.
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Genomic context

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See GLB1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 8

Sequence:: Chromosome: 4; NC_003075.7 (821546..823569)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis PII Proteins Form Characteristic Foci in Chloroplasts Indicating Novel Properties in Protein Interaction and Degradation.
Title: Arabidopsis PII Proteins Form Characteristic Foci in Chloroplasts Indicating Novel Properties in Protein Interaction and Degradation.
The production of both Nitric oxide (NO) and ethylene gases was increased with reduced expression of either of the Hb genes GLB1 or GLB2, whereas NO emission decreased in plants overexpressing these genes.
Title: Haemoglobin modulates NO emission and hyponasty under hypoxia-related stress in Arabidopsis thaliana.
Over-expression of GLB1 and GLB2 induces shoot formation at low levels of cytokinins.
Title: Manipulation of hemoglobin expression affects Arabidopsis shoot organogenesis.
role in the fine tuning of fatty acid biosynthesis and partitioning in seeds
Title: PII is induced by WRINKLED1 and fine-tunes fatty acid composition in seeds of Arabidopsis thaliana.
These data show that PII function has evolved between bacterial and plant systems to control the carbon metabolism pathway of fatty acid synthesis in plastids, through regulation of acetyl-CoA carboxylase activity.
Title: Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit.
These results reveal a complex metabolic control of the PII interaction with NAGK in the chloroplast stroma of higher plants.
Title: Metabolite regulation of the interaction between Arabidopsis thaliana PII and N-acetyl-l-glutamate kinase.
A light-dependent nitrite uptake into chloroplasts is increased in PII knock-out mutants.
Title: Chloroplast nitrite uptake is enhanced in Arabidopsis PII mutants.
Data show that the major Arabidopsis PII-interacting protein is the chloroplast-localized enzyme N-acetyl glutamate kinase, which catalyzes the key regulatory step in the pathway to arginine biosynthesis.
Title: The PII signal transduction protein of Arabidopsis thaliana forms an arginine-regulated complex with plastid N-acetyl glutamate kinase.
data support the hypothesis of a subtle involvement of the PII protein in the regulation of some steps of primary C and N metabolism
Title: Physiological characterisation of Arabidopsis mutants affected in the expression of the putative regulatory protein PII.
crystal structure; a highly conserved segment at the N-terminus that is found only in plant PII forms numerous interactions with the alpha2 helix and projects from the surface of the homotrimer opposite to that occupied by the T-loop
Title: Crystal structure of Arabidopsis PII reveals novel structural elements unique to plants.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_116421.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables acetylglutamate kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of arginine biosynthetic process via ornithine	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nitrogen utilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to sucrose	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast thylakoid	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in plastid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nitrogen regulatory P-II-like protein

NP_192099.1

GLNB1 homolog (GLB1); FUNCTIONS IN: acetylglutamate kinase regulator activity; INVOLVED IN: response to light stimulus, nitrogen compound metabolic process, regulation of arginine biosynthetic process via ornithine, anthocyanin biosynthetic process, response to sucrose stimulus; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal (InterPro:IPR015867), Nitrogen regulatory protein PII (InterPro:IPR002187), Nitrogen regulatory protein PII, conserved site (InterPro:IPR017918), Nitrogen regulatory PII-like, alpha/beta (InterPro:IPR011322); Has 6977 Blast hits to 6975 proteins in 1636 species: Archae - 359; Bacteria - 5100; Metazoa - 0; Fungi - 0; Plants - 60; Viruses - 0; Other Eukaryotes - 1458 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

821546..823569

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116421.4 → NP_192099.1 nitrogen regulatory P-II-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192099.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9ZST4

UniProtKB/TrEMBL

A0A5S9XPT0

Conserved Domains (1) summary

smart00938
Location:77 → 179

P-II; Nitrogen regulatory protein P-II