U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VTE1 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829413, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VTE1
    Official Full Name
    tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1)
    Primary source
    TAIR:AT4G32770
    Locus tag
    AT4G32770
    See related
    Araport:AT4G32770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSDX1; F4D11.30; F4D11_30; SUCROSE EXPORT DEFECTIVE 1; VITAMIN E DEFICIENT 1
    Summary
    Tocopherol cyclase involved in tocopherol (vitamin E)synthesis. VTE1 over-expressing plants have increased tocopherol indicating VTE1 is a major limiting factor in tocopherol synthesis. Mutants defective in this gene accumulate high amounts of zeaxanthin in conditions of high light or low temperature. Plays a role in the adaptation to low temperature stress, notably phloem loading.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VTE1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (15804784..15808084)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ENTH/VHS/GAT family protein Neighboring gene tRNA-Ser Neighboring gene phosphoinositide binding protein Neighboring gene Exostosin family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The functional network of the Arabidopsis plastoglobule proteome based on quantitative proteomics and genome-wide coexpression analysis. Lundquist PK, et al. Plant Physiol, 2012 Mar. PMID 22274653, Free PMC Article
    2. Alterations in tocopherol cyclase activity in transgenic and mutant plants of Arabidopsis affect tocopherol content, tocopherol composition, and oxidative stress. Kanwischer M, et al. Plant Physiol, 2005 Feb. PMID 15665245, Free PMC Article
    3. Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function. Sattler SE, et al. Plant Physiol, 2003 Aug. PMID 12913173, Free PMC Article
    4. A chloroplast ABC1-like kinase regulates vitamin E metabolism in Arabidopsis. Martinis J, et al. Plant Physiol, 2013 Jun. PMID 23632854, Free PMC Article
    5. Inactivation of genes, encoding tocopherol biosynthetic pathway enzymes, results in oxidative stress in outdoor grown Arabidopsis thaliana. Semchuk NM, et al. Plant Physiol Biochem, 2009 May. PMID 19264498

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABC1K3 phosphorylates VTE1, possibly stabilizing it at plastoglobules.
      Title: A chloroplast ABC1-like kinase regulates vitamin E metabolism in Arabidopsis.
    2. Results show that both vte1 and vte4 mutant plant lines had higher concentration of protein carbonyl groups and oxidized glutathione compared to the wild type, indicating the development of oxidative stress.
      Title: Inactivation of genes, encoding tocopherol biosynthetic pathway enzymes, results in oxidative stress in outdoor grown Arabidopsis thaliana.
    3. Evaluation of tocopherol cyclase over- and under-expression on metabolism of tocopheol, ascorbate, glutathione, and oxidative stress in A. thaliana transgenics and mutants.
      Title: Alterations in tocopherol cyclase activity in transgenic and mutant plants of Arabidopsis affect tocopherol content, tocopherol composition, and oxidative stress.
    4. analysis of VTE1 localization and vitamin E accumulation in chloroplast plastoglobule lipoprotein particles
      Title: Tocopherol cyclase (VTE1) localization and vitamin E accumulation in chloroplast plastoglobule lipoprotein particles.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_119430.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables tocopherol cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tocopherol cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chlorophyll metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem sucrose loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to high light intensity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vitamin E biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vitamin E biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xanthophyll metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plastoglobule HDA PubMed 
    located_in plastoglobule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1)
    NP_567906.1
    • VITAMIN E DEFICIENT 1 (VTE1); FUNCTIONS IN: tocopherol cyclase activity; INVOLVED IN: in 9 processes; LOCATED IN: chloroplast, plastoglobule, chloroplast inner membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15804784..15808084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119430.5 → NP_567906.1  tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65524, Q94FY7
      UniProtKB/TrEMBL
      A0A178UWD9, A0A5S9XY16, A0A654FV06, Q0WW11
      Conserved Domains (1) summary
      PLN02818
      Location:74 → 477
      PLN02818; tocopherol cyclase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94FY7.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools