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    CRN Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831170, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRN
    Official Full Name
    Protein kinase superfamily protein
    Primary source
    TAIR:AT5G13290
    Locus tag
    AT5G13290
    See related
    Araport:AT5G13290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CORYNE; SOL2; SUPPRESSOR OF LLP1 2; T31B5.110; T31B5_110
    Summary
    Encodes a protein with predicted Ser/Thr kinase activity and membrane localization that is involved in the CLV3 signaling pathway that represses WUS expression in the meristem. Loss of function of CRN can suppress the phenotype caused by overexpression of CLV3. SOL2 isolated as a suppressor of root- specific overexpression of CLE19, a clavata3 like gene. sol2 partially suppresses the short root phenotype caused by CLE19 overexpression. Mutant flowers have extra carpels.
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    Genomic context

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    See CRN in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (4252842..4255378, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myosin Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene aspartate kinase 1 Neighboring gene uncharacterized protein Neighboring gene ARF GTPase-activating protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved pseudokinase mediates stem cell production in plants. Nimchuk ZL, et al. Plant Cell, 2011 Mar. PMID 21398569, Free PMC Article
    2. The receptor-like kinase SOL2 mediates CLE signaling in Arabidopsis. Miwa H, et al. Plant Cell Physiol, 2008 Nov. PMID 18854335, Free PMC Article
    3. CLAVATA Signaling Ensures Reproductive Development in Plants across Thermal Environments. Jones DS, et al. Curr Biol, 2021 Jan 11. PMID 33157018, Free PMC Article
    4. Shared and distinct functions of the pseudokinase CORYNE (CRN) in shoot and root stem cell maintenance of Arabidopsis. Somssich M, et al. J Exp Bot, 2016 Aug. PMID 27229734, Free PMC Article
    5. Recessive antimorphic alleles overcome functionally redundant loci to reveal TSO1 function in Arabidopsis flowers and meristems. Sijacic P, et al. PLoS Genet, 2011 Nov. PMID 22072982, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLAVATA Signaling Ensures Reproductive Development in Plants across Thermal Environments.
      Title: CLAVATA Signaling Ensures Reproductive Development in Plants across Thermal Environments.
    2. SOL1 and SOL2 regulate fate transition and cell divisions in the Arabidopsis stomatal lineage.
      Title: SOL1 and SOL2 regulate fate transition and cell divisions in the Arabidopsis stomatal lineage.
    3. study reports that the receptor-like protein CLAVATA 2 (CLV2) and the pseudokinase CORYNE (CRN) are necessary to fully sense root-active CLE peptides; CRN stabilizes BAM3 expression and thus is required for BAM3-mediated CLE45 signaling.
      Title: Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature.
    4. the class I phenotype can be mimicked by knocking out both TSO1 and its homolog SOL2 in double mutants.
      Title: Recessive antimorphic alleles overcome functionally redundant loci to reveal TSO1 function in Arabidopsis flowers and meristems.
    5. Our results suggest a model in which CLV1/BAM1 and CLV2/CRN complexes act in separate, parallel pathways in shoot meristems, while the CLV1, CLV2, and CRN receptors function together in a linear pathway during fruit development.
      Title: CLAVATA signaling pathway receptors of Arabidopsis regulate cell proliferation in fruit organ formation as well as in meristems.
    6. A 12-mer random-peptide library was used to determine the specific amino acid sequences binding with the recombinant CRN molecule.
      Title: Identification of target ligands of CORYNE in Arabidopsis by phage display library.
    7. CRN contains features of a pseudokinase but lacks kinase activity
      Title: An evolutionarily conserved pseudokinase mediates stem cell production in plants.
    8. The results therefore imply that the CLE14/CLE20 peptides may act through the CLV2-CRN receptor kinase, and that their availabilities and/or abundances may be affected by cytokinin activity in planta.
      Title: CLE14/CLE20 peptides may interact with CLAVATA2/CORYNE receptor-like kinases to irreversibly inhibit cell division in the root meristem of Arabidopsis.
    9. Data show that CRN, rather than CLV1 and CLV2, was able to form homodimers without CLV3 stimulation.
      Title: Analysis of interactions among the CLAVATA3 receptors reveals a direct interaction between CLAVATA2 and CORYNE in Arabidopsis.
    10. This study suggested that the CLV3 signal is perceived by a tetrameric CLV2/CRN complex and a CLV1 homodimer that localize to the PM and can interact via CRN.
      Title: Stem cell signaling in Arabidopsis requires CRN to localize CLV2 to the plasma membrane.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085108.1
    NM_121332.4
    NM_180481.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptide receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of root meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phloem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meristem growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of root meristem growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_001078577.1
    • CORYNE (CRN); FUNCTIONS IN: protein kinase activity, kinase activity, ATP binding; INVOLVED IN: regulation of meristem growth, regulation of root meristem growth, meristem maintenance, regulation of flower development; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT2G31880.1); Has 55771 Blast hits to 55472 proteins in 1453 species: Archae - 44; Bacteria - 2468; Metazoa - 16951; Fungi - 4037; Plants - 25285; Viruses - 100; Other Eukaryotes - 6886 (source: NCBI BLink).
    NP_196833.2
    • CORYNE (CRN); FUNCTIONS IN: protein kinase activity, kinase activity, ATP binding; INVOLVED IN: regulation of meristem growth, regulation of root meristem growth, meristem maintenance, regulation of flower development; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT2G31880.1); Has 90342 Blast hits to 89573 proteins in 2628 species: Archae - 105; Bacteria - 9194; Metazoa - 31524; Fungi - 7067; Plants - 29119; Viruses - 228; Other Eukaryotes - 13105 (source: NCBI BLink).
    NP_850812.2
    • CORYNE (CRN); FUNCTIONS IN: protein kinase activity, kinase activity, ATP binding; INVOLVED IN: regulation of meristem growth, regulation of root meristem growth, meristem maintenance, regulation of flower development; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT2G31880.1); Has 92136 Blast hits to 91345 proteins in 2709 species: Archae - 107; Bacteria - 9592; Metazoa - 32171; Fungi - 7128; Plants - 29600; Viruses - 232; Other Eukaryotes - 13306 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4252842..4255378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180481.4 → NP_850812.2  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850812.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRZ3, Q3E9I0, Q9LYU7
      UniProtKB/TrEMBL
      A0A5S9Y4A7, A0A654G0N8
      Conserved Domains (2) summary
      cd14066
      Location:124 → 398
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam00069
      Location:121 → 394
      Pkinase; Protein kinase domain

    2. NM_001085108.1 → NP_001078577.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LYU7
      Conserved Domains (1) summary
      cl21453
      Location:120 → 274
      PKc_like; Protein Kinases, catalytic domain

    3. NM_121332.4 → NP_196833.2  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196833.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y4A7, A0A654G0N8
      Conserved Domains (1) summary
      cd14066
      Location:120 → 373
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LYU7.1

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