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    HB5 homeobox protein 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836656, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HB5
    Official Full Name
    homeobox protein 5
    Primary source
    TAIR:AT5G65310
    Locus tag
    AT5G65310
    See related
    Araport:AT5G65310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHB-5; ATHB5; homeobox protein 5; MNA5.4; MNA5_4
    Summary
    Encodes a class I HDZip (homeodomain-leucine zipper) protein that is a positive regulator of ABA-responsiveness, mediating the inhibitory effect of ABA on growth during seedling establishment.
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    Genomic context

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    See HB5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (26101818..26104614, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Met Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene AGAMOUS-like 78

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Source-to-sink partitioning is altered by changes in the expression of the transcription factor AtHB5 in Arabidopsis. Raminger BL, et al. J Exp Bot, 2023 Mar 28. PMID 36622804
    2. The Transcription Factor ATHB5 Affects GA-Mediated Plasticity in Hypocotyl Cell Growth during Seed Germination. Stamm P, et al. Plant Physiol, 2017 Jan. PMID 27872245, Free PMC Article
    3. The Arabidopsis thaliana homeobox gene ATHB5 is a potential regulator of abscisic acid responsiveness in developing seedlings. Johannesson H, et al. Plant Mol Biol, 2003 Mar. PMID 12678559
    4. Transcriptional repression of BODENLOS by HD-ZIP transcription factor HB5 in Arabidopsis thaliana. De Smet I, et al. J Exp Bot, 2013 Jul. PMID 23682118, Free PMC Article
    5. Expression patterns of novel genes encoding homeodomain leucine-zipper proteins in Arabidopsis thaliana. Söderman E, et al. Plant Mol Biol, 1994 Oct. PMID 7948864

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Source-to-sink partitioning is altered by changes in the expression of the transcription factor AtHB5 in Arabidopsis.
      Title: Source-to-sink partitioning is altered by changes in the expression of the transcription factor AtHB5 in Arabidopsis.
    2. ATHB5 is a hypocotyl specific growth regulatory factor during seed germination.
      Title: The Transcription Factor ATHB5 Affects GA-Mediated Plasticity in Hypocotyl Cell Growth during Seed Germination.
    3. HB5 negatively regulates BDL expression.
      Title: Transcriptional repression of BODENLOS by HD-ZIP transcription factor HB5 in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001037074.2
    NM_125929.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of abscisic acid-activated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein 5
    NP_001032151.1
    • homeobox protein 5 (HB5); FUNCTIONS IN: sequence-specific DNA binding, transcription activator activity, protein homodimerization activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of transcription, abscisic acid mediated signaling pathway, regulation of abscisic acid mediated signaling pathway, regulation of transcription, DNA-dependent, response to abscisic acid stimulus; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Helix-turn-helix motif, lambda-like repressor (InterPro:IPR000047), Leucine zipper, homeobox-associated (InterPro:IPR003106), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox protein 16 (TAIR:AT4G40060.1); Has 10595 Blast hits to 10554 proteins in 566 species: Archae - 0; Bacteria - 4; Metazoa - 8208; Fungi - 200; Plants - 1989; Viruses - 5; Other Eukaryotes - 189 (source: NCBI BLink).
    NP_201334.1
    • homeobox protein 5 (HB5); FUNCTIONS IN: sequence-specific DNA binding, transcription activator activity, protein homodimerization activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of transcription, abscisic acid mediated signaling pathway, regulation of abscisic acid mediated signaling pathway, regulation of transcription, DNA-dependent, response to abscisic acid stimulus; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Helix-turn-helix motif, lambda-like repressor (InterPro:IPR000047), Homeodomain-like (InterPro:IPR009057), Leucine zipper, homeobox-associated (InterPro:IPR003106), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox protein 16 (TAIR:AT4G40060.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26101818..26104614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125929.3 → NP_201334.1  homeobox protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201334.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46667
      UniProtKB/TrEMBL
      A0A178U859
      Conserved Domains (2) summary
      pfam00046
      Location:79 → 125
      Homeobox; Homeobox domain
      pfam02183
      Location:127 → 168
      HALZ; Homeobox associated leucine zipper

    2. NM_001037074.2 → NP_001032151.1  homeobox protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032151.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U859, F4KHX1
      Conserved Domains (2) summary
      pfam00046
      Location:61 → 107
      Homeobox; Homeobox domain
      pfam02183
      Location:109 → 150
      HALZ; Homeobox associated leucine zipper
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46667.1

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