CKA1 casein kinase alpha 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: CKA1
Official Full Name: casein kinase alpha 1
Primary source: TAIR:AT5G67380
Locus tag: AT5G67380
See related: Araport:AT5G67380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCKA1; ATPK12D; casein kinase alpha 1; K8K14.10; K8K14_10
Summary: Casein kinase II (CK2) catalytic subunit (alpha 1). One known substrate of CK2 is Phytochrome Interacting Factor 1 (PIF1). CK2-mediated phosphorylation enhances the light-induced degradation of PIF1 to promote photomorphogenesis.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See CKA1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 10

Sequence:: Chromosome: 5; NC_003076.8 (26880966..26884079, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CK2 alpha subunits affect diverse developmental and stress responsive pathways in Arabidopsis.
Title: Casein kinase II α subunits affect multiple developmental and stress-responsive pathways in Arabidopsis.
CK2 is required in the maintenance and control of genomic stability and chromatin structure in plants, and that this process affects several functions, including the DNA damage response and DNA repair.[CK2]
Title: CK2-defective Arabidopsis plants exhibit enhanced double-strand break repair rates and reduced survival after exposure to ionizing radiation.
The high pleiotropy of CK2 was sustained by analysis of global transcript profiles that showed a huge number of genes affected, involved in a wide variety of cellular processes.
Title: About the role of CK2 in plant signal transduction.
The effects of a cka1a2a3 triple mutant on the Arabidopsis (Arabidopsis thaliana) circadian clock, were examined.
Title: A role for protein kinase casein kinase2 α-subunits in the Arabidopsis circadian clock.
alpha1 and alpha2 subunits of CK2 individually phosphorylated phytochrome interacting factors weakly in vitro.
Title: Phosphorylation by CK2 enhances the rapid light-induced degradation of phytochrome interacting factor 1 in Arabidopsis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_001037088.2

Supported by ESTs:

NM_126138.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within DNA repair	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chromatin organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chromatin organization	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to UV-C	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
part_of protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: casein kinase alpha 1

NP_001032165.1

casein kinase alpha 1 (CKA1); FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: casein kinase II, alpha chain 2 (TAIR:AT3G50000.1); Has 73369 Blast hits to 72658 proteins in 2362 species: Archae - 60; Bacteria - 7223; Metazoa - 28693; Fungi - 10783; Plants - 10981; Viruses - 246; Other Eukaryotes - 15383 (source: NCBI BLink).

NP_201539.2

casein kinase alpha 1 (CKA1); FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: casein kinase II, alpha chain 2 (TAIR:AT3G50000.1); Has 85531 Blast hits to 84684 proteins in 2530 species: Archae - 70; Bacteria - 9546; Metazoa - 32860; Fungi - 11294; Plants - 14699; Viruses - 299; Other Eukaryotes - 16763 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26880966..26884079 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126138.4 → NP_201539.2 casein kinase alpha 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201539.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DH00, B9DHA8, F4K3Q1, Q08467, Q94F17, Q9FN14

UniProtKB/TrEMBL

A0A178UCK1, A0A5S9YIY2

Conserved Domains (2) summary

cd14132
Location:91 → 395

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

pfam00069
Location:110 → 395

Pkinase; Protein kinase domain
NM_001037088.2 → NP_001032165.1 casein kinase alpha 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001032165.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9YIY2

Conserved Domains (2) summary

cd14132
Location:91 → 362

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

cl21464
Location:33 → 137

cupin_like; Conserved domain found in cupin and related proteins