Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnab1provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related subfamily, beta member 1provided by MGI
Primary source: MGI:MGI:109155
See related: Ensembl:ENSMUSG00000027827 AllianceGenome:MGI:109155
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Akr8a8; Kvbeta1.1; mKv(beta)1
Summary: Predicted to enable several functions, including NADPH binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Acts upstream of or within learning or memory and regulation of potassium ion transmembrane transporter activity. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and perikaryon. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Is expressed in brain; heart; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 15.7), cortex adult (RPKM 8.2) and 5 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 E1; 3 30.15 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (64856636..65285643)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (64949212..65378225)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins.
Title: Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
Data, including data from studies in knockout mice, suggest that association/disassociation of subunits Kcnma1 and Kcnab1 of the BK channel (large-conductance calcium-activated potassium channel) is involved in function of coronary artery smooth muscle cells and their dysfunction during ischemia/reperfusion-induced myocardial injury in diabetes.
Title: Coronary arterial BK channel dysfunction exacerbates ischemia/reperfusion-induced myocardial injury in diabetic mice.
Kvbeta1 differentially regulates the functional cell surface expression of myocardial I(to,f) and I(K,slow2) channels.
Title: Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

X97281 (e-PCR)
- UniSTS:125900

35.MMHAP59FLD5.seq (e-PCR)
- UniSTS:124148

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISS Inferred from Sequence or Structural Similarity more info
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbonyl reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of potassium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in proximal dendrite	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IC Inferred by Curator more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: voltage-gated potassium channel subunit beta-1

Names: K(+) channel subunit beta-1; voltage dependent potassium channel subunit beta-1

NP_001276379.1

EC 1.1.1.-

NP_001344287.1

EC 1.1.1.-

NP_001390801.1

EC 1.1.1.-

NP_034727.3

EC 1.1.1.-

XP_006501120.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289450.2 → NP_001276379.1 voltage-gated potassium channel subunit beta-1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC113279, AC119855, AC134550

UniProtKB/TrEMBL

Q3U6C5, Q9D5E9

Related

ENSMUST00000161404.8

Conserved Domains (1) summary

cl00470
Location:1 → 287

AKR_SF; Aldo-keto reductase (AKR) superfamily
NM_001357358.2 → NP_001344287.1 voltage-gated potassium channel subunit beta-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC113279, AC113458, AC134550

Consensus CDS

CCDS89632.1

UniProtKB/TrEMBL

A0A5F8MPK0

Related

ENSMUSP00000159000.2, ENSMUST00000238901.2

Conserved Domains (1) summary

TIGR01293
Location:91 → 407

Kv_beta; voltage-dependent potassium channel beta subunit, animal
NM_001403872.1 → NP_001390801.1 voltage-gated potassium channel subunit beta-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC113458, AC134550

UniProtKB/TrEMBL

Q8CD65

Related

ENSMUST00000159525.8
NM_010597.6 → NP_034727.3 voltage-gated potassium channel subunit beta-1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC113279, AC113458, AC134550

Consensus CDS

CCDS38447.1

UniProtKB/Swiss-Prot

P63143, P97380, Q61763, Q63277, Q91WM5

UniProtKB/TrEMBL

Q9D5E9

Related

ENSMUSP00000047480.9, ENSMUST00000049230.11

Conserved Domains (1) summary

cd19159
Location:71 → 393

AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

64856636..65285643

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501057.1 → XP_006501120.1 voltage-gated potassium channel subunit beta-1 isoform X1

UniProtKB/TrEMBL

A0A5F8MPA4, Q9D5E9

Related

ENSMUSP00000158882.2, ENSMUST00000239069.2

Conserved Domains (1) summary

cd19159
Location:78 → 400

AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins