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    GstD3 Glutathione S transferase D3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48336, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstD3provided by FlyBase
    Official Full Name
    Glutathione S transferase D3provided by FlyBase
    Primary source
    FLYBASE:FBgn0010039
    Locus tag
    Dmel_CG4381
    See related
    AllianceGenome:FB:FBgn0010039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP11313; CG4381; D3; Dmel\CG4381; DmGST22; DmGSTD3; gst; Gst; GST-D3; gstD22; GstD22; gstd3; gstD3; GSTD3
    Summary
    Predicted to be involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and posterior endoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstD3 in Genome Data Viewer
    Location:
    87B8-87B8; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12373068..12373813)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8198790..8199535)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46015 Neighboring gene Glutathione S transferase D2 Neighboring gene Glutathione S transferase D4 Neighboring gene Glutathione S transferase D5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PARTICIPATION OF Y89 AND Y97 IN THE CONJUGATING ACTIVITY OF Drosophila melanogaster GLUTATHIONE S-TRANSFERASE D3 (DmGSTD3). Vignesvaran K, et al. Arch Insect Biochem Physiol, 2016 Jul. PMID 27075600
    2. Behavioral and Transcriptional Response to Selection for Olfactory Behavior in Drosophila. Brown EB, et al. G3 (Bethesda), 2020 Apr 9. PMID 32024668, Free PMC Article
    3. The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila melanogaster. Toung YP, et al. J Biol Chem, 1993 May 5. PMID 7683659
    4. Identification of methylmercury tolerance gene candidates in Drosophila. Mahapatra CT, et al. Toxicol Sci, 2010 Jul. PMID 20375079, Free PMC Article
    5. Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. Zhao HW, et al. J Biol Chem, 2011 Feb 25. PMID 21148307, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase D3
    Names
    CG4381-PA
    Glutathione-S-transferase D3
    GstD3-PA
    glutathione S transferase D22

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12373068..12373813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176479.2 → NP_788656.1  glutathione S transferase D3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT68, Q9VG97
      Related
      FBpp0082042
      Conserved Domains (3) summary
      cd03177
      Location:72 → 188
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:6 → 173
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:1 → 58
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAB26513.1
    Q9VG97.1 Q9VG97

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