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    Reln reelin [ Mus musculus (house mouse) ]

    Gene ID: 19699, updated on 4-Jan-2025

    Summary

    Official Symbol
    Relnprovided by MGI
    Official Full Name
    reelinprovided by MGI
    Primary source
    MGI:MGI:103022
    See related
    Ensembl:ENSMUSG00000042453 AllianceGenome:MGI:103022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rl; reeler
    Summary
    Enables receptor ligand activity; serine-type peptidase activity; and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; positive regulation of cell communication; and regulation of neurotransmitter receptor activity. Acts upstream of or within several processes, including nervous system development; peptidyl-tyrosine phosphorylation; and thyroid hormone metabolic process. Located in cytoplasm; dendrite; and extracellular matrix. Is active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; and familial temporal lobe epilepsy 7. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in cerebellum adult (RPKM 15.8), CNS E18 (RPKM 13.9) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Reln in Genome Data Viewer
    Location:
    5 A3; 5 9.98 cM
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22089452..22549703, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21884454..22344705, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene solute carrier family 26, member 5 Neighboring gene STARR-seq mESC enhancer starr_12580 Neighboring gene STARR-seq mESC enhancer starr_12582 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene 10475 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene Neighboring gene predicted gene, 57737 Neighboring gene predicted gene, 54324 Neighboring gene STARR-seq mESC enhancer starr_12584 Neighboring gene predicted gene, 42223 Neighboring gene predicted gene, 25459 Neighboring gene STARR-seq mESC enhancer starr_12585 Neighboring gene STARR-seq mESC enhancer starr_12586 Neighboring gene origin recognition complex, subunit 5 Neighboring gene ribosomal protein L22 like 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 74
    Process Evidence Code Pubs
    involved_in NMDA glutamate receptor clustering PubMed 
    involved_in associative learning PubMed 
    involved_in associative learning PubMed 
    acts_upstream_of_or_within axon guidance PubMed 
    acts_upstream_of_or_within brain development PubMed 
    involved_in cell adhesion  
    acts_upstream_of_or_within cell migration PubMed 
    acts_upstream_of_or_within cell morphogenesis PubMed 
    involved_in central nervous system development  
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within cerebral cortex development PubMed 
    acts_upstream_of_or_within cerebral cortex tangential migration PubMed 
    acts_upstream_of_or_within dendrite development PubMed 
    acts_upstream_of_or_within dendrite development PubMed 
    involved_in dentate gyrus development  
    acts_upstream_of_or_within forebrain development PubMed 
    acts_upstream_of_or_within glial cell differentiation PubMed 
    involved_in hippocampus development PubMed 
    acts_upstream_of_or_within interneuron migration PubMed 
    involved_in lateral motor column neuron migration PubMed 
    involved_in layer formation in cerebral cortex PubMed 
    acts_upstream_of_or_within layer formation in cerebral cortex PubMed 
    involved_in learning PubMed 
    acts_upstream_of_or_within locomotory behavior PubMed 
    involved_in locomotory behavior  
    involved_in long-term memory PubMed 
    involved_in long-term memory PubMed 
    involved_in long-term synaptic potentiation PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    acts_upstream_of_or_within motor neuron migration PubMed 
    involved_in neuron migration  
    acts_upstream_of_or_within neuron migration PubMed 
    acts_upstream_of_or_within neuron migration PubMed 
    involved_in neuron migration  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of AMPA receptor activity PubMed 
    involved_in positive regulation of CREB transcription factor activity PubMed 
    involved_in positive regulation of TOR signaling PubMed 
    involved_in positive regulation of dendritic spine morphogenesis PubMed 
    involved_in positive regulation of dendritic spine morphogenesis PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of lateral motor column neuron migration PubMed 
    involved_in positive regulation of long-term synaptic potentiation PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of protein kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of protein kinase activity PubMed 
    involved_in positive regulation of protein tyrosine kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction PubMed 
    involved_in positive regulation of synapse maturation PubMed 
    involved_in positive regulation of synapse maturation PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in postsynaptic density assembly PubMed 
    involved_in postsynaptic density protein 95 clustering PubMed 
    involved_in protein localization to synapse PubMed 
    involved_in proteolysis  
    involved_in receptor localization to synapse PubMed 
    involved_in reelin-mediated signaling pathway PubMed 
    involved_in reelin-mediated signaling pathway PubMed 
    involved_in regulation of NMDA receptor activity PubMed 
    involved_in regulation of behavior PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of neuron differentiation PubMed 
    involved_in regulation of neuron migration PubMed 
    involved_in regulation of synapse maturation PubMed 
    involved_in regulation of synapse maturation PubMed 
    involved_in regulation of synaptic activity PubMed 
    acts_upstream_of_or_within response to pain PubMed 
    acts_upstream_of_or_within spinal cord patterning PubMed 
    acts_upstream_of_or_within thyroid hormone metabolic process  
    involved_in ventral spinal cord development PubMed 
    Items 1 - 25 of 74
    Component Evidence Code Pubs
    located_in axon  
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm PubMed 
    located_in dendrite PubMed 
    located_in dendrite  
    located_in extracellular matrix PubMed 
    located_in extracellular matrix PubMed 
    is_active_in extracellular space  
    is_active_in extracellular space PubMed 
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in neuron projection  
    located_in neuronal cell body  
    located_in perikaryon  
    located_in plasma membrane  
    part_of reelin complex  

    General protein information

    Preferred Names
    reelin
    Names
    extracellular matrix serine protease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310464.1NP_001297393.1  reelin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC113028, AC116404, AC119906, AC121878
      Consensus CDS
      CCDS80217.1
      UniProtKB/Swiss-Prot
      Q60841
      Related
      ENSMUSP00000058025.8, ENSMUST00000062372.14
      Conserved Domains (20) summary
      cd10036
      Location:203352
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:527672
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:8681035
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:12411410
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:16061775
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:19602131
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:23232479
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:26702854
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:30563230
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:709863
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:10661221
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:14481598
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:18011938
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:21662315
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:25152662
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:28903051
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:32673427
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:422557
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd08544
      Location:49179
      Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam07974
      Location:21312160
      EGF_2; EGF-like domain
    2. NM_011261.2NP_035391.2  reelin isoform 1 precursor

      See identical proteins and their annotated locations for NP_035391.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC113028, AC116404, AC119906, AC121878
      Consensus CDS
      CCDS39023.1
      UniProtKB/Swiss-Prot
      E9PZ78, Q60841, Q9CUA6
      Related
      ENSMUSP00000124052.2, ENSMUST00000161356.8
      Conserved Domains (20) summary
      cd10036
      Location:203352
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:527672
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:8681035
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:12411410
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:16061775
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:19602131
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:23232479
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:26702854
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:30563230
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:709863
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:10661221
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:14481598
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:18011938
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:21662315
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:25152662
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:28903051
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:32673427
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:422557
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd08544
      Location:49179
      Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam07974
      Location:21312160
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      22089452..22549703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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