Shfl shiftless antiviral inhibitor of ribosomal frameshifting [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shflprovided by MGI
Official Full Name: shiftless antiviral inhibitor of ribosomal frameshiftingprovided by MGI
Primary source: MGI:MGI:2441788
See related: Ensembl:ENSMUSG00000038884 AllianceGenome:MGI:2441788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RyDEN; A230050P20Rik
Summary: Predicted to enable identical protein binding activity; ribosome binding activity; and sequence-specific mRNA binding activity. Predicted to be involved in several processes, including defense response to symbiont; regulation of translation; and viral translational frameshifting. Predicted to be located in P-body; cytosol; and nucleoplasm. Is expressed in midbrain. Orthologous to human SHFL (shiftless antiviral inhibitor of ribosomal frameshifting). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 29.2), cortex adult (RPKM 29.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.65 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20779914..20785603)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (20868635..20874307)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis.
Title: Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translational frameshifting	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational frameshifting	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translational termination	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational termination	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type I interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type I interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type III interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type III interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral translational frameshifting	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral translational frameshifting	ISO Inferred from Sequence Orthology more info
involved_in viral translational frameshifting	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: shiftless antiviral inhibitor of ribosomal frameshifting protein homolog

Names: UPF0515 protein C19orf66 homolog; repressor of yield of DENV protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.