U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cnot7 CCR4-NOT transcription complex, subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 18983, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cnot7provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 7provided by MGI
    Primary source
    MGI:MGI:1298230
    See related
    Ensembl:ENSMUSG00000031601 AllianceGenome:MGI:1298230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Caf1; Pop2; CAF-1
    Summary
    Enables piRNA binding activity and poly(A)-specific ribonuclease activity. Involved in positive regulation of mRNA catabolic process and spermatogenesis. Acts upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in P-body and nucleus. Part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and skeleton. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E14 (RPKM 22.0), CNS E18 (RPKM 21.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cnot7 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40945579..40968888, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40492538..40515847, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene STARR-seq mESC enhancer starr_21271 Neighboring gene STARR-seq mESC enhancer starr_21272 Neighboring gene ADAM metallopeptidase domain 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables RNA exonuclease activity  
    enables RNA exonuclease activity  
    enables metal ion binding  
    enables piRNA binding PubMed 
    enables poly(A)-specific ribonuclease activity  
    enables poly(A)-specific ribonuclease activity PubMed 
    enables poly(A)-specific ribonuclease activity  
    enables protein binding PubMed 
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    acts_upstream_of_or_within P-body assembly PubMed 
    acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA PubMed 
    acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA  
    involved_in defense response to virus  
    involved_in defense response to virus  
    involved_in miRNA-mediated gene silencing by mRNA destabilization  
    involved_in miRNA-mediated gene silencing by mRNA destabilization  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of type I interferon-mediated signaling pathway  
    involved_in negative regulation of type I interferon-mediated signaling pathway  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening  
    involved_in piRNA-mediated gene silencing by mRNA destabilization PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of mRNA catabolic process  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of viral genome replication  
    involved_in positive regulation of viral genome replication  
    involved_in regulation of translation  
    involved_in regulation of tyrosine phosphorylation of STAT protein  
    involved_in regulatory ncRNA-mediated gene silencing PubMed 
    involved_in spermatogenesis PubMed 
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    part_of CCR4-NOT complex PubMed 
    part_of CCR4-NOT complex  
    part_of CCR4-NOT core complex  
    is_active_in P-body  
    located_in P-body PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    is_active_in intracellular membraneless organelle  
    located_in nuclear body  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 7
    Names
    CCR4-associated factor 1
    POP2 homolog
    catabolite repressor protein (CCR4)-associative factor 1
    NP_001258471.1
    NP_001258472.1
    NP_001348867.1
    NP_001348868.1
    NP_035265.1
    XP_006509370.1
    XP_036009723.1
    XP_036009724.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271542.1NP_001258471.1  CCR4-NOT transcription complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_001258471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC118012, AK135669, AK147048
      Consensus CDS
      CCDS22253.1
      UniProtKB/Swiss-Prot
      Q60809
      UniProtKB/TrEMBL
      Q3V231, Q543X5
      Related
      ENSMUSP00000122933.2, ENSMUST00000132032.8
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    2. NM_001271543.1NP_001258472.1  CCR4-NOT transcription complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001258472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC118012
      Consensus CDS
      CCDS72114.1
      UniProtKB/TrEMBL
      Q3TLK9, Q3V231
      Related
      ENSMUSP00000119319.2, ENSMUST00000135269.8
      Conserved Domains (1) summary
      cl23804
      Location:1215
      CAF1; CAF1 family ribonuclease
    3. NM_001361938.1NP_001348867.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CN663584
      Consensus CDS
      CCDS22253.1
      UniProtKB/Swiss-Prot
      Q60809
      UniProtKB/TrEMBL
      Q3V231, Q543X5
      Related
      ENSMUSP00000117304.2, ENSMUST00000149992.2
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    4. NM_001361939.1NP_001348868.1  CCR4-NOT transcription complex subunit 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CJ166755
      UniProtKB/TrEMBL
      Q3V231
      Conserved Domains (1) summary
      cl23804
      Location:1292
      CAF1; CAF1 family ribonuclease
    5. NM_011135.5NP_035265.1  CCR4-NOT transcription complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_035265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform . Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC118012, AK147048, CJ166755
      Consensus CDS
      CCDS22253.1
      UniProtKB/Swiss-Prot
      Q60809
      UniProtKB/TrEMBL
      Q3V231, Q543X5
      Related
      ENSMUSP00000034012.4, ENSMUST00000034012.10
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease

    RNA

    1. NR_155265.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CJ166755, CN663584, DV653062
    2. NR_155266.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CN663584, DV653062

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      40945579..40968888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153830.1XP_036009723.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/TrEMBL
      Q3V231
      Conserved Domains (1) summary
      cl23804
      Location:1228
      CAF1; CAF1 family ribonuclease
    2. XM_036153831.1XP_036009724.1  CCR4-NOT transcription complex subunit 7 isoform X2

      UniProtKB/TrEMBL
      Q3TLK9, Q3V231
      Conserved Domains (1) summary
      cl23804
      Location:1215
      CAF1; CAF1 family ribonuclease
    3. XM_006509307.3XP_006509370.1  CCR4-NOT transcription complex subunit 7 isoform X3

      Conserved Domains (1) summary
      cl23804
      Location:1173
      CAF1; CAF1 family ribonuclease

    RNA

    1. XR_378909.4 RNA Sequence

    External link. Please review our privacy policy.