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    Gorab Golgin, RAB6 interacting [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gorabprovided by FlyBase
    Official Full Name
    Golgin, RAB6 interactingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053052
    Locus tag
    Dmel_CG33052
    See related
    AllianceGenome:FB:FBgn0053052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33052; CG3882; Dmel\CG33052; gorab
    Summary
    Enables identical protein binding activity. Involved in positive regulation of centriole replication; positive regulation of cilium assembly; and positive regulation of cytokinesis. Located in Golgi apparatus subcompartment and microtubule organizing center. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in geroderma osteodysplasticum. Orthologous to human GORAB (golgin, RAB6 interacting). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gorab in Genome Data Viewer
    Location:
    74B4-74B5; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17427305..17428836, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17420405..17421936, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 7B Neighboring gene RNA polymerase III subunit G Neighboring gene Coenzyme Q4 Neighboring gene fringe connection Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab. Kovacs L, et al. Biol Open, 2022 Nov 1. PMID 36331102, Free PMC Article
    2. Gorab is a Golgi protein required for structure and duplication of Drosophila centrioles. Kovacs L, et al. Nat Genet, 2018 Jul. PMID 29892014, Free PMC Article
    3. The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication. Fatalska A, et al. Elife, 2021 Mar 11. PMID 33704067, Free PMC Article
    4. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    5. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab.
      Title: Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab.
    2. The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.
      Title: The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgin, RAB6 interacting
    Names
    CG33052-PA
    Gorab-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17427305..17428836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176345.3 → NP_788523.1  Golgin, RAB6 interacting [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788523.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQQ4, Q8SZQ5
      Related
      FBpp0074991
      Conserved Domains (1) summary
      pfam04949
      Location:200 → 316
      Transcrip_act; Transcriptional activator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQQ4.1 Q8IQQ4

    Gene LinkOut

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