Bcar3 breast cancer anti-estrogen resistance 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcar3provided by MGI
Official Full Name: breast cancer anti-estrogen resistance 3provided by MGI
Primary source: MGI:MGI:1352501
See related: Ensembl:ENSMUSG00000028121 AllianceGenome:MGI:1352501
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AND-34
Summary: Predicted to enable kinase binding activity and phosphotyrosine residue binding activity. Acts upstream of or within lens morphogenesis in camera-type eye and positive regulation of peptidyl-serine phosphorylation. Located in focal adhesion and membrane. Is expressed in brain; retina; submandibular gland primordium; testis; and tongue epithelium. Orthologous to human BCAR3 (BCAR3 adaptor protein, NSP family member). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 13.2), subcutaneous fat pad adult (RPKM 13.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 53.41 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (122213406..122323840)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (122419757..122530191)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by Disrupting Macrophage-Fibroblast Crosstalk.
Title: Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by Disrupting Macrophage-Fibroblast Crosstalk.
The first spontaneous mutation in the Bcar3 gene associated with lens extrusion cataracts.
Title: A novel spontaneous mutation of BCAR3 results in extrusion cataracts in CF#1 mouse strain.
data presented here suggest that Bcar3 could play a role in testis development
Title: Bcar3 is expressed in sertoli cells and germ cells of the developing testis in mice.
many BCAR3-mediated signaling events in epithelial and mesenchymal cells are independent of p130Cas association
Title: BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.
AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens.
Title: Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens.
study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1)
Title: Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance.
p130Cas- and HEF1-associated AND-34 may regulate B cell adhesion and motility through a Cdc42-mediated signaling pathway.
Title: The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bcar3 (e-PCR), detects polymorphism
- UniSTS:547584

AI131758 (e-PCR)
- UniSTS:163331

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endothelin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lens morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: breast cancer anti-estrogen resistance protein 3 homolog

Names: p130Cas-binding protein AND-34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355264.1 → NP_001342193.1 breast cancer anti-estrogen resistance protein 3 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC138720

Conserved Domains (2) summary

cd10337
Location:57 → 191

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:454 → 729

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_013867.3 → NP_038895.1 breast cancer anti-estrogen resistance protein 3 homolog isoform 1

See identical proteins and their annotated locations for NP_038895.1

Status: VALIDATED

Source sequence(s)

AC138720, AF179566, AV223564

Consensus CDS

CCDS17810.1

UniProtKB/Swiss-Prot

Q3TNC9, Q3UP10, Q9QZK2

Related

ENSMUSP00000029766.5, ENSMUST00000029766.9

Conserved Domains (2) summary

cd10337
Location:142 → 276

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:539 → 814

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

122213406..122323840

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501559.5 → XP_006501622.1 breast cancer anti-estrogen resistance protein 3 homolog isoform X1

Conserved Domains (1) summary

cl02485
Location:190 → 465

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...