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    comm2 comm2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    comm2provided by FlyBase
    Official Full Name
    comm2provided by FlyBase
    Primary source
    FLYBASE:FBgn0041160
    Locus tag
    Dmel_CG7554
    See related
    AllianceGenome:FB:FBgn0041160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7554; Comm2; Dmel\CG7554
    Summary
    Predicted to be involved in axon guidance. Is expressed in several structures, including amnioserosa primordium; anlage in statu nascendi; embryonic/larval midgut primordium; epithelium; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See comm2 in Genome Data Viewer
    Location:
    71F1-71F1; 3-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15697594..15699850, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15690694..15692950, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for commissureless2 function during dipteran insect nerve cord development. Sarro J, et al. Dev Dyn, 2013 Dec. PMID 24026811, Free PMC Article
    2. Comm sorts robo to control axon guidance at the Drosophila midline. Keleman K, et al. Cell, 2002 Aug 23. PMID 12202032
    3. The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. Justice ED, et al. PLoS Genet, 2017 Aug. PMID 28859078, Free PMC Article
    4. Genome-wide analysis of promoter architecture in Drosophila melanogaster. Hoskins RA, et al. Genome Res, 2011 Feb. PMID 21177961, Free PMC Article
    5. Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy. Arbel H, et al. Proc Natl Acad Sci U S A, 2019 Jan 15. PMID 30598455, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Commissureless2 function is required for dipteran nerve cord development.
      Title: Requirement for commissureless2 function during dipteran insect nerve cord development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    comm2
    Names
    CG7554-PA
    comm2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15697594..15699850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140544.2 → NP_648801.2  comm2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648801.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZ29, Q9VUT8
      Related
      FBpp0075333
      Conserved Domains (1) summary
      pfam15957
      Location:113 → 224
      Comm; Commissureless
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUT8.2 Q9VUT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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