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    Frl Formin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frlprovided by FlyBase
    Official Full Name
    Formin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267795
    Locus tag
    Dmel_CG32138
    See related
    AllianceGenome:FB:FBgn0267795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.98; CG13485; CG32138; CG43986; CG6807; Dmel\CG32138; frl; Q9VUC5_DROME; Q9VUC6_DROME
    Old locus tag
    Dmel_CG43986
    Summary
    Enables small GTPase binding activity. Involved in axon extension; mushroom body development; and ommatidial rotation. Predicted to be active in cytosol. Is expressed in adult head and adult tracheal system. Orthologous to several human genes including FMNL3 (formin like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Frl in Genome Data Viewer
    Location:
    70D1-70D1; 3-42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14053215..14071583)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14046796..14064683)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Neuralized E3 ubiquitin protein ligase 4 Neighboring gene antisense RNA:CR46067 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peroxin 1 Neighboring gene breathless Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular Dissection of DAAM Function during Axon Growth in Drosophila Embryonic Neurons. Földi I, et al. Cells, 2022 Apr 28. PMID 35563792, Free PMC Article
    2. Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability. Dehapiot B, et al. Nat Cell Biol, 2020 Jul. PMID 32483386
    3. A Comparative Study of the Role of Formins in Drosophila Embryonic Dorsal Closure. Tóth K, et al. Cells, 2022 May 4. PMID 35563844, Free PMC Article
    4. Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors. Vu A, et al. Mol Cell Neurosci, 2018 Dec. PMID 30149064
    5. Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior. Das R, et al. Development, 2021 Aug 15. PMID 34322714, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.
      Title: FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.
    2. Frl likely contributes to ommatidial rotation during eye development; Frl cooperates with DAAM during axon growth in the mushroom body
      Title: Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Formin-like
    Names
    CG32138-PA
    CG32138-PB
    CG32138-PC
    CG32138-PD
    Frl-PA
    Frl-PB
    Frl-PC
    Frl-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14053215..14071583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144476.3 → NP_001137948.1  Formin-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137948.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUC6
      Conserved Domains (3) summary
      pfam02181
      Location:678 → 1054
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:365 → 558
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:77 → 362
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_168575.4 → NP_729954.2  Formin-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729954.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z050, M9PCF8, Q86NT2, Q9VUC5, Q9VUC6
      Conserved Domains (3) summary
      pfam02181
      Location:687 → 1063
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:374 → 567
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:77 → 371
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. NM_001274895.2 → NP_001261824.1  Formin-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261824.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCF8
      Conserved Domains (3) summary
      pfam02181
      Location:678 → 1054
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:365 → 558
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:77 → 362
      Drf_GBD; Diaphanous GTPase-binding Domain

    4. NM_168576.4 → NP_729955.2  Formin-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729955.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUC6
      Conserved Domains (3) summary
      pfam02181
      Location:678 → 1054
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:365 → 558
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:77 → 362
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUC6.3 Q9VUC6

    Gene LinkOut

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