APP-BP1 beta-Amyloid precursor protein binding protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: APP-BP1provided by FlyBase
Official Full Name: beta-Amyloid precursor protein binding protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0261112
Locus tag: Dmel_CG7828
See related: AllianceGenome:FB:FBgn0261112
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0140519.225; APP; APPBP1; CG7828; dAPP-BP1; dAPPBP1; Dmel\CG7828
Summary: Enables amyloid-beta binding activity. Contributes to NEDD8 activating enzyme activity. Involved in protein neddylation. Part of NAE1-UBA3 complex. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 68A6-68A6; 3-34 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11098412..11100578)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11091512..11093678)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that APP-BP1 specifically binds the intracellular domain of APP-like protein (APPL), APP-BP1 mutation partially suppresses the abnormal macrochaete phenotype of Appl(d), while overexpression of dAPP-BP1 causes abnormal macrochaetes.
Title: Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to NEDD8 activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables NEDD8 activating enzyme activity	IEA Inferred from Electronic Annotation more info
contributes_to NEDD8 activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein neddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info
involved_in protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of NAE1-UBA3 complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: beta-Amyloid precursor protein binding protein 1

Names: APP-BP1-PA; APP-BP1-PB; CG7828-PA; CG7828-PB

NP_001261699.1

EC 6.2.1.45

NP_648435.1

EC 6.2.1.45

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11098412..11100578

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140178.4 → NP_648435.1 beta-Amyloid precursor protein binding protein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648435.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B6IDX9, Q8IHE1, Q9VTE9

UniProtKB/TrEMBL

M9PEU5

Related

FBpp0075938

Conserved Domains (2) summary

COG0476
Location:17 → 171

ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]

cd01493
Location:16 → 522

APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
NM_001274770.1 → NP_001261699.1 beta-Amyloid precursor protein binding protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261699.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B6IDX9, Q8IHE1, Q9VTE9

UniProtKB/TrEMBL

M9PEU5

Conserved Domains (2) summary

COG0476
Location:17 → 171

ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]

cd01493
Location:16 → 522

APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...