Ilp4 Insulin-like peptide 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ilp4provided by FlyBase
Official Full Name: Insulin-like peptide 4provided by FlyBase
Primary source: FLYBASE:FBgn0044049
Locus tag: Dmel_CG6736
See related: AllianceGenome:FB:FBgn0044049
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A; anon-EST:CLB3; BcDNA:RE27042; CG6736; dilp; Dilp; DILP; Dilp 4; DILP 4; dilp-4; DILP-4; Dilp1-5; dilp4; dIlp4; dILP4; Dilp4; DILP4; DILPs; Dirlp; dlp; Dmel\CG6736; Ilp; Ilp-4; ilp4; ILP4; ILPs; mes3; Mes3
Summary: Predicted to enable G protein-coupled receptor binding activity and insulin receptor binding activity. Involved in larval feeding behavior. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including anlage in statu nascendi; circulatory system primordium; endoderm anlage; mesoderm; and midgut. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human INSL3 (insulin like 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9803399..9804263, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9796499..9797363, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG6736-PA; Ilp4-PA; drosophila insulin-like peptide 4; drosophila insulin/relaxin-like peptide; insulin-like peptide; insulin-like peptide-4; insulin/insulin-like growth factor

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The following sections contain reference sequences that belong to a specific genome build. Explain