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    Ilp1 Insulin-like peptide 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ilp1provided by FlyBase
    Official Full Name
    Insulin-like peptide 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0044051
    Locus tag
    Dmel_CG14173
    See related
    AllianceGenome:FB:FBgn0044051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14173; dilp; dILP; Dilp; DILP; Dilp 1; DILP 1; dilp-1; Dilp-1; DILP-1; dilp1; dILP1; Dilp1; DILP1; Dilp1-5; DILPs; dlp; Dmel\CG14173; Ilp; Ilp-1; ilp1; ILP1; ILPs
    Summary
    Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including insulin secreting cell of pars intercerebralis; larval brain; larval pars intercerebralis; and pars intercerebralis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ilp1 in Genome Data Viewer
    Location:
    67C8-67C8; 3-31 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9798420..9799050)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9791534..9791998)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Anion exchanger 2 Neighboring gene uncharacterized protein Neighboring gene Z band alternatively spliced PDZ-motif protein 67 Neighboring gene Insulin-like peptide 2 Neighboring gene Insulin-like peptide 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Making Feeding Decisions in the Drosophila Nervous System. Miroschnikow A, et al. Curr Biol, 2020 Jul 20. PMID 32693083
    2. Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster. Lee KS, et al. FEBS Lett, 2009 Aug 6. PMID 19619547
    3. The Drosophila retained/dead ringer gene and ARID gene family function during development. Shandala T, et al. Int J Dev Biol, 2002. PMID 12141428
    4. Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling. Ostojic I, et al. Proc Natl Acad Sci U S A, 2014 Jun 3. PMID 24847072, Free PMC Article
    5. Altered sperm fate in the reproductive tract milieu due to oxidative stress leads to sub-fertility in type 1 diabetes females: A Drosophila-based study. Gupta HP, et al. Life Sci, 2023 Jan 15. PMID 36543282

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dilp2 modulates lifespan in part by regulating Akh, and by repressing dilp1, which acts as a pro-longevity insulin-like peptide.
      Title: Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2.
    2. DILP1 is expressed in non-feeding stages and in diapausing flies, is under feedback regulation and appears to play sex-specific functional roles.
      Title: Drosophila insulin-like peptide 1 (DILP1) is transiently expressed during non-feeding stages and reproductive dormancy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Insulin-like peptide 1
    Names
    CG14173-PA
    Ilp1-PA
    drosophila insulin-like peptide
    drosophila insulin-like peptide 1
    insulin-like peptide
    insulin/insulin-like growth factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9798420..9799050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140102.2 → NP_648359.1  Insulin-like peptide 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VT50
      UniProtKB/TrEMBL
      C9QPG9, E7BBS0
      Related
      FBpp0076057
      Conserved Domains (1) summary
      cd04366
      Location:131 → 151
      IlGF_insulin_bombyxin_like; IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides including insulin, insulin-like growth factors I and II, insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT50.1 Q9VT50

    Gene LinkOut

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