Pus7 Pseudouridine synthase 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pus7provided by FlyBase
Official Full Name: Pseudouridine synthase 7provided by FlyBase
Primary source: FLYBASE:FBgn0035901
Locus tag: Dmel_CG6745
See related: AllianceGenome:FB:FBgn0035901
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6745; CT20937; Dmel\CG6745; pus7; PUS7
Summary: Enables pseudouridine synthase activity. Involved in tRNA pseudouridine synthesis. Predicted to be active in nucleus. Is expressed in anterior midgut primordium; embryonic/larval midgut; gonad; organism; and posterior midgut primordium. Used to study intellectual developmental disorder with abnormal behavior, microcephaly, and short stature. Human ortholog(s) of this gene implicated in intellectual developmental disorder with abnormal behavior, microcephaly, and short stature. Orthologous to human PUS7 (pseudouridine synthase 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8510003..8513007)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8503103..8506107)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA pseudouridine(13) synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in tRNA pseudouridine synthesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain