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    Bulli bulli [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bulliprovided by FlyBase
    Official Full Name
    bulliprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035703
    Locus tag
    Dmel_CG8270
    See related
    AllianceGenome:FB:FBgn0035703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bulli; CG8270; Dmel\CG8270
    Summary
    Enables guanyl-nucleotide exchange factor adaptor activity. Predicted to be involved in regulation of autophagy. Part of Mon1-Ccz1 complex. Is expressed in adult head. Orthologous to human RMC1 (regulator of MON1-CCZ1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bulli in Genome Data Viewer
    Location:
    65B3-65B3; 3-17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6488681..6491210)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6481781..6484310)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45979 Neighboring gene Vacuolar protein sorting 8 Neighboring gene sulfateless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Yong X, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216550, Free PMC Article
    2. A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. Dehnen L, et al. J Cell Sci, 2020 Jul 9. PMID 32499409
    3. Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation. Borchers AC, et al. Proc Natl Acad Sci U S A, 2023 Jul 25. PMID 37463208, Free PMC Article
    4. A conserved and regulated mechanism drives endosomal Rab transition. Langemeyer L, et al. Elife, 2020 May 11. PMID 32391792, Free PMC Article
    5. Endolysosomal trafficking controls yolk granule biogenesis in vitellogenic Drosophila oocytes. Yu Y, et al. PLoS Genet, 2024 Feb. PMID 38315726, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mon1-Ccz1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Mon1-Ccz1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bulli
    Names
    Bulli-PB
    CG8270-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6488681..6491210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139790.3 → NP_648047.2  bulli [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648047.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0HDN5, Q9VRX1
      Conserved Domains (1) summary
      pfam07035
      Location:461 → 616
      Mic1; Colon cancer-associated protein Mic1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRX1 Q9VRX1

    Gene LinkOut

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