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    Mid1 Mid1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mid1provided by FlyBase
    Official Full Name
    Mid1provided by FlyBase
    Primary source
    FLYBASE:FBgn0053988
    Locus tag
    Dmel_CG33988
    See related
    AllianceGenome:FB:FBgn0053988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13595; cg13596; CG13596; CG18510; CG33988; Dmel\CG33988; mid1; Nlf-1
    Summary
    Contributes to leak channel activity. Involved in locomotor rhythm and social behavior. Part of cation channel complex. Is expressed in dorsal ectoderm; ganglia; sensory cluster; ventral ectoderm; and ventral nerve cord primordium. Orthologous to human NALF1 (NALCN channel auxiliary factor 1) and NALF2 (NALCN channel auxiliary factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mid1 in Genome Data Viewer
    Location:
    60D14-60D16; 2-107 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24695378..24736657, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20582901..20624180, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Painting of fourth Neighboring gene Matrix metalloproteinase 1 Neighboring gene Sialyltransferase Neighboring gene long non-coding RNA:CR44828 Neighboring gene Ubiquitin specific protease 15/31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity. Moose DL, et al. Front Cell Neurosci, 2017. PMID 28634443, Free PMC Article
    2. New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN. Monteil A, et al. Physiol Rev, 2024 Jan 1. PMID 37615954
    3. A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Flourakis M, et al. Cell, 2015 Aug 13. PMID 26276633, Free PMC Article
    4. Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals. Ghezzi A, et al. Front Mol Neurosci, 2014. PMID 24639627, Free PMC Article
    5. Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States. Tabuchi M, et al. Front Neurol, 2021. PMID 33854471, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to leak channel activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to stretch-activated, monoatomic cation-selective, calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhythmic behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mid1
    Names
    CG33988-PA
    CG33988-PB
    Mid1 ortholog
    Mid1-PA
    Mid1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24695378..24736657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274241.1 → NP_001261170.1  Mid1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWK9, Q9I7V0
      Conserved Domains (1) summary
      pfam12929
      Location:651 → 676
      Mid1; Stretch-activated Ca2+-permeable channel component

    2. NM_001038883.2 → NP_001033972.1  Mid1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWK9, Q9I7V0
      Conserved Domains (1) summary
      pfam12929
      Location:651 → 676
      Mid1; Stretch-activated Ca2+-permeable channel component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7V0 Q9I7V0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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