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    Ube2f ubiquitin-conjugating enzyme E2F (putative) [ Mus musculus (house mouse) ]

    Gene ID: 67921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ube2fprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2F (putative)provided by MGI
    Primary source
    MGI:MGI:1915171
    See related
    Ensembl:ENSMUSG00000034343 AllianceGenome:MGI:1915171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510010F15Rik
    Summary
    Enables NEDD8 transferase activity. Involved in protein neddylation. Predicted to be active in cytosol and nucleus. Orthologous to human UBE2F (ubiquitin conjugating enzyme E2 F (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.6), placenta adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2f in Genome Data Viewer
    Location:
    1 D; 1 46.08 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91177412..91214243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91249690..91286521)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93080001-93080198 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93089975-93090287 Neighboring gene receptor (calcitonin) activity modifying protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9471 Neighboring gene STARR-positive B cell enhancer ABC_E498 Neighboring gene STARR-positive B cell enhancer ABC_E794 Neighboring gene zinc finger protein 330 pseudogene Neighboring gene selenocysteine lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Wu D, et al. Nat Commun, 2022 May 31. PMID 35641500, Free PMC Article
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. The UBE2F-CRL5(ASB11)-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells. Chang Y, et al. Dev Cell, 2024 May 20. PMID 38574733
    4. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Huang DT, et al. Mol Cell, 2009 Feb 27. PMID 19250909, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NEDD8 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NEDD8 transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NEDD8 transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8-conjugating enzyme UBE2F
    Names
    NEDD8 carrier protein UBE2F
    NEDD8 protein ligase UBE2F
    NEDD8-conjugating enzyme 2
    RING-type E3 NEDD8 transferase UBE2F
    ubiquitin-conjugating enzyme E2 F
    NP_001342690.1
    NP_001342691.1
    NP_001342692.1
    NP_001342693.1
    NP_080730.1
    XP_006529901.1
    XP_011246369.1
    XP_017177752.1
    XP_030098417.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355761.1 → NP_001342690.1  NEDD8-conjugating enzyme UBE2F

      Status: VALIDATED

      Source sequence(s)
      AC102874, AK010957, AK030594, BB621519, BQ032120
      Consensus CDS
      CCDS48322.1
      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Related
      ENSMUSP00000054303.6, ENSMUST00000059743.12
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001355762.1 → NP_001342691.1  NEDD8-conjugating enzyme UBE2F

      Status: VALIDATED

      Source sequence(s)
      AK030594, BB621519, BQ032120
      Consensus CDS
      CCDS48322.1
      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Related
      ENSMUSP00000126173.2, ENSMUST00000171165.8
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_001355763.1 → NP_001342692.1  NEDD8-conjugating enzyme UBE2F

      Status: VALIDATED

      Source sequence(s)
      AC102874, AK007937, BB621519, BQ032120, CO430243
      Consensus CDS
      CCDS48322.1
      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Related
      ENSMUSP00000140743.2, ENSMUST00000191368.7
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_001355764.1 → NP_001342693.1  NEDD8-conjugating enzyme UBE2F

      Status: VALIDATED

      Source sequence(s)
      AC102874
      Consensus CDS
      CCDS48322.1
      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Related
      ENSMUSP00000131330.2, ENSMUST00000171112.8
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. NM_026454.4 → NP_080730.1  NEDD8-conjugating enzyme UBE2F

      See identical proteins and their annotated locations for NP_080730.1

      Status: VALIDATED

      Source sequence(s)
      AK030594, AK153481, BB621519, BQ032120
      Consensus CDS
      CCDS48322.1
      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Related
      ENSMUSP00000136915.2, ENSMUST00000178627.8
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RNA

    1. NR_149825.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK030594, BB621519, BQ032120, CX219989

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91177412..91214243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322263.1 → XP_017177752.1  NEDD8-conjugating enzyme UBE2F isoform X1

      Conserved Domains (1) summary
      cl00154
      Location:63 → 207
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. XM_011248067.3 → XP_011246369.1  NEDD8-conjugating enzyme UBE2F isoform X2

      See identical proteins and their annotated locations for XP_011246369.1

      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. XM_006529838.5 → XP_006529901.1  NEDD8-conjugating enzyme UBE2F isoform X2

      See identical proteins and their annotated locations for XP_006529901.1

      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. XM_030242557.2 → XP_030098417.1  NEDD8-conjugating enzyme UBE2F isoform X2

      UniProtKB/Swiss-Prot
      Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY34.1 GenPept UniProtKB/Swiss-Prot:Q9CY34

    Gene LinkOut

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