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    Tcn2 transcobalamin 2 [ Mus musculus (house mouse) ]

    Gene ID: 21452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcn2provided by MGI
    Official Full Name
    transcobalamin 2provided by MGI
    Primary source
    MGI:MGI:98534
    See related
    Ensembl:ENSMUSG00000020432 AllianceGenome:MGI:98534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcn-2
    Summary
    Enables cargo receptor ligand activity and cobalamin binding activity. Involved in cobalamin transport. Is active in external side of plasma membrane and extracellular space. Is expressed in central nervous system; eye; genitourinary system; and liver. Human ortholog(s) of this gene implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Orthologous to human TCN2 (transcobalamin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 764.5), large intestine adult (RPKM 133.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcn2 in Genome Data Viewer
    Location:
    11 A1; 11 2.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3867077..3882078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3917077..3932078, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921536K21 gene Neighboring gene dual specificity phosphatase 18 Neighboring gene solute carrier family 35, member E4 Neighboring gene STARR-seq mESC enhancer starr_28367 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene pescadillo ribosomal biogenesis factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transport of vitamin B12 into mouse leukemia cells. DiGirolamo PM, et al. Arch Biochem Biophys, 1975 Jun. PMID 237480
    2. Allelic forms of mouse transcobalamin 2. Fràter-Schröder M, et al. Biochem Genet, 1982 Oct. PMID 7181844
    3. Mouse transcobalamin has features resembling both human transcobalamin and haptocorrin. Hygum K, et al. PLoS One, 2011. PMID 21655200, Free PMC Article
    4. The murine leukemia inhibition factor gene (Lif) is located on proximal chromosome 11, not chromosome 13. Bottorff D, et al. Mamm Genome, 1992. PMID 1477476
    5. Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter. Boachie J, et al. Int J Mol Sci, 2021 Mar 17. PMID 33803025, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
      Title: Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cargo receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cargo receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cobalamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cobalamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cobalamin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular carrier activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cobalamin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cobalamin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cobalamin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cobalamin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cobalt ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcobalamin-2
    Names
    TC II
    TC-2
    TCII
    transcobalamin II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130458.1 → NP_001123930.1  transcobalamin-2 precursor

      See identical proteins and their annotated locations for NP_001123930.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AK133707, AK143761, BB849607
      Consensus CDS
      CCDS24371.1
      UniProtKB/Swiss-Prot
      O88968, Q3TD34, Q3UP69, Q5SQ21
      Related
      ENSMUSP00000105620.3, ENSMUST00000109993.9
      Conserved Domains (2) summary
      pfam01122
      Location:11 → 327
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:355 → 428
      DUF4430; Domain of unknown function (DUF4430)

    2. NM_001130459.1 → NP_001123931.1  transcobalamin-2 precursor

      See identical proteins and their annotated locations for NP_001123931.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AK143761, AK147176
      Consensus CDS
      CCDS24371.1
      UniProtKB/Swiss-Prot
      O88968, Q3TD34, Q3UP69, Q5SQ21
      Related
      ENSMUSP00000105617.2, ENSMUST00000109990.8
      Conserved Domains (2) summary
      pfam01122
      Location:11 → 327
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:355 → 428
      DUF4430; Domain of unknown function (DUF4430)

    3. NM_015749.3 → NP_056564.1  transcobalamin-2 precursor

      See identical proteins and their annotated locations for NP_056564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1
      Source sequence(s)
      AK143761, AK147176, BB844284
      Consensus CDS
      CCDS24371.1
      UniProtKB/Swiss-Prot
      O88968, Q3TD34, Q3UP69, Q5SQ21
      Related
      ENSMUSP00000105616.4, ENSMUST00000109989.10
      Conserved Domains (2) summary
      pfam01122
      Location:11 → 327
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:355 → 428
      DUF4430; Domain of unknown function (DUF4430)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3867077..3882078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514611.3 → XP_006514674.1  transcobalamin-2 isoform X1

      See identical proteins and their annotated locations for XP_006514674.1

      UniProtKB/Swiss-Prot
      O88968, Q3TD34, Q3UP69, Q5SQ21
      Related
      ENSMUSP00000105618.2, ENSMUST00000109991.8
      Conserved Domains (2) summary
      pfam01122
      Location:11 → 327
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:355 → 428
      DUF4430; Domain of unknown function (DUF4430)

    2. XM_006514610.5 → XP_006514673.1  transcobalamin-2 isoform X1

      See identical proteins and their annotated locations for XP_006514673.1

      UniProtKB/Swiss-Prot
      O88968, Q3TD34, Q3UP69, Q5SQ21
      Related
      ENSMUSP00000020710.5, ENSMUST00000020710.11
      Conserved Domains (2) summary
      pfam01122
      Location:11 → 327
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:355 → 428
      DUF4430; Domain of unknown function (DUF4430)

    3. XM_006514612.4 → XP_006514675.1  transcobalamin-2 isoform X1

      See identical proteins and their annotated locations for XP_006514675.1

      UniProtKB/Swiss-Prot
      O88968, Q3TD34, Q3UP69, Q5SQ21
      Related
      ENSMUSP00000105619.2, ENSMUST00000109992.8
      Conserved Domains (2) summary
      pfam01122
      Location:11 → 327
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:355 → 428
      DUF4430; Domain of unknown function (DUF4430)

    4. XM_006514613.4 → XP_006514676.1  transcobalamin-2 isoform X1

      See identical proteins and their annotated locations for XP_006514676.1

      UniProtKB/Swiss-Prot
      O88968, Q3TD34, Q3UP69, Q5SQ21
      Related
      ENSMUSP00000105615.2, ENSMUST00000109988.2
      Conserved Domains (2) summary
      pfam01122
      Location:11 → 327
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:355 → 428
      DUF4430; Domain of unknown function (DUF4430)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88968.1 GenPept UniProtKB/Swiss-Prot:O88968

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