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    a arc [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aprovided by FlyBase
    Official Full Name
    arcprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000008
    Locus tag
    Dmel_CG6741
    See related
    AllianceGenome:FB:FBgn0000008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arc; bran; CG13505; CG6741; Dmel\CG6741
    Summary
    Involved in compound eye development. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including Malpighian tubule; embryonic/larval salivary gland; eye disc morphogenetic furrow; gut section; and imaginal disc. Orthologous to human LNX1 (ligand of numb-protein X 1); LNX2 (ligand of numb-protein X 2); and STXBP4 (syntaxin binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    58C1-58C5; 2-98 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22136968..22172834)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18024473..18060339)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Golgi matrix protein 130 kD Neighboring gene uncharacterized protein Neighboring gene NtR Neighboring gene uncharacterized protein Neighboring gene gomdanji Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45151 Neighboring gene uncharacterized protein Neighboring gene F-box protein 42 Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CoFly: A gene coexpression database for the fruit fly Drosophila melanogaster. Liu W, et al. Arch Insect Biochem Physiol, 2020 Sep. PMID 32436316
    2. New facts on dependent, successive and conjugated spontaneous mutation. GOLDSCHMIDT RB. J Exp Zool, 1947 Mar. PMID 20290998
    3. Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling. Miyashita T, et al. Cell Rep, 2018 Dec 4. PMID 30517860
    4. The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth. Szuplewski S, et al. Development, 2003 Aug. PMID 12835382
    5. The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. Goossens T, et al. Development, 2011 Apr. PMID 21389050, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arc
    Names
    CG6741-PA
    CG6741-PB
    CG6741-PC
    CG6741-PD
    a-PA
    a-PB
    a-PC
    a-PD
    broad angular

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22136968..22172834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166514.2 → NP_726168.1  arc, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W283, Q9W284
      Related
      FBpp0071677
      Conserved Domains (1) summary
      cd00992
      Location:1230 → 1317
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001014543.2 → NP_001014543.1  arc, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W283, Q9W284
      Conserved Domains (1) summary
      cd00992
      Location:1230 → 1317
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. NM_001299777.1 → NP_001286706.1  arc, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG21
      Conserved Domains (1) summary
      cd00992
      Location:988 → 1075
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    4. NM_079902.3 → NP_524641.1  arc, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W283, Q9W284
      Related
      FBpp0071678
      Conserved Domains (1) summary
      cd00992
      Location:1230 → 1317
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG21 A0A0B4LG21
    Q9W283 Q9W283

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