Esrp2 epithelial splicing regulatory protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esrp2provided by MGI
Official Full Name: epithelial splicing regulatory protein 2provided by MGI
Primary source: MGI:MGI:1924661
See related: Ensembl:ENSMUSG00000084128 AllianceGenome:MGI:1924661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rbm35b; 9530027K23Rik
Summary: Predicted to enable mRNA binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in stomach adult (RPKM 34.4), liver adult (RPKM 30.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.1 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106856658..106863825, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106130319..106137193, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma through altering FGFR2 splicing and macrophage polarization.
Title: Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma through altering FGFR2 splicing and macrophage polarization.
An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates.
Title: An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates.
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
Title: Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
Data show that the hypomethylated lncRNAs, 1810019D21Rik (called Esrp2-antisense (as)) was identified in proximity to the epithelial splicing regulatory protein 2 (Esrp2) that is significantly elevated in C3(1) tumors.
Title: Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer.
Loss of both Esrp1 and its paralog Esrp2 results in widespread developmental defects with broad implications to human disease.
Title: The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.
Findings define a direct role for ESRP2 in the generation of conserved repertoires of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes.
Title: ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation.
deltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta-induced EMT and the progression of breast cancers
Title: TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.
Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 splicing.
Title: ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

Rbm35b (e-PCR), detects polymorphism
- UniSTS:479136

NoName (e-PCR)
- UniSTS:235989

Esrp2 (e-PCR), detects polymorphism
- UniSTS:548063

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: epithelial splicing regulatory protein 2

Names: RNA binding motif protein 35b; RNA-binding motif protein 35B; RNA-binding protein 35B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176838.2 → NP_789808.1 epithelial splicing regulatory protein 2

See identical proteins and their annotated locations for NP_789808.1

Status: PROVISIONAL

Source sequence(s)

BC031444

Consensus CDS

CCDS22629.1

UniProtKB/Swiss-Prot

Q8CEK2, Q8K0G8

UniProtKB/TrEMBL

D3Z139

Related

ENSMUSP00000111639.3, ENSMUST00000115979.9

Conserved Domains (4) summary

cd12507
Location:248 → 322

RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins

cd12742
Location:464 → 544

RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins

cl10012
Location:82 → 214

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl17169
Location:332 → 438

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

106856658..106863825 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243854.2 → XP_030099714.1 epithelial splicing regulatory protein 2 isoform X2

Conserved Domains (4) summary

PHA03247
Location:423 → 532

PHA03247; large tegument protein UL36; Provisional

cd12737
Location:116 → 195

RRM1_ESRP2; RNA recognition motif 1 in epithelial splicing regulatory protein 2 (ESRP2) and similar proteins

cd12742
Location:332 → 412

RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins

cl17169
Location:200 → 306

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006531492.4 → XP_006531555.1 epithelial splicing regulatory protein 2 isoform X1

UniProtKB/TrEMBL

D3Z139

Conserved Domains (5) summary

PHA03247
Location:554 → 663

PHA03247; large tegument protein UL36; Provisional

cd12507
Location:247 → 321

RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins

cd12742
Location:463 → 543

RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins

cl10012
Location:82 → 214

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl17169
Location:331 → 437

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011248547.3 → XP_011246849.1 epithelial splicing regulatory protein 2 isoform X3

Conserved Domains (3) summary

cd12507
Location:248 → 322

RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins

cl10012
Location:82 → 214

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl17169
Location:332 → 433

RRM_SF; RNA recognition motif (RRM) superfamily